Background Mental health is a complex condition, highly related to emotion. The COVID-19 pandemic caused a significant spike in depression (from isolation) and anxiety (event related). Mobile Health (mHealth) and telemedicine offer solutions to augment patient care, provide education, improve symptoms of depression, and assuage fears and anxiety. Objective This review aims to assess the effectiveness of mHealth to provide mental health care by analyzing articles published in the last year in peer-reviewed, academic journals using strong methodology (randomized controlled trial). Methods We queried 4 databases (PubMed, CINAHL [Cumulative Index to Nursing and Allied Health Literature], Web of Science, and ScienceDirect) using a standard Boolean search string. We conducted this systematic literature review in accordance with the Kruse protocol and reported it in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) 2020 checklist (n=33). Results A total of 4 interventions (mostly mHealth) from 14 countries identified improvements in primary outcomes of depression and anxiety as well as in several secondary outcomes, namely, quality of life, mental well-being, cognitive flexibility, distress, sleep, self-efficacy, anger, decision conflict, decision regret, digestive disturbance, pain, and medication adherence. Conclusions mHealth interventions can provide education, treatment augmentation, and serve as the primary modality in mental health care. The mHealth modality should be carefully considered when evaluating modes of care. Trial Registration PROSPERO International Prospective Register of Systematic Reviews CRD42022343489; https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=343489

BACKGROUND Mental health is a complex condition, highly related to emotion. The COVID-19 pandemic caused a significant spike in depression (from isolation) and anxiety (event related). mHealth and telemedicine offer solutions to augment patient care, provide education, improve symptoms of depression and assuage fears and anxiety. OBJECTIVE The objective of this review is to assess the effectiveness of mHealth to provide mental healthcare by analyzing articles published in the last year in peer-reviewed, academic journals using strong methodology (RCT). METHODS We queried four databases (PubMed, CINAHL, Web of Science, and ScienceDirect) using a standard Boolean search string. We conducted this systematic literature review in accordance with the Kruse Protocol, and we reported it in accordance with PRISMA 2020 (n=33). RESULTS Four interventions (mostly mHealth) from 14 countries identified improvements in both primary outcomes of depression and anxiety as well as several secondary outcomes: quality of life, mental well-being, cognitive flexibility, distress, sleep, self-efficacy, anger, decision conflict, decision regret, digestive disturbance, pain, and medication adherence. CONCLUSIONS mHealth interventions can provide education, treatment augmentation, and serve as the primary modality in mental healthcare. While it is not touted as a panacea, the modality should be carefully considered when evaluating modes of care. CLINICALTRIAL This review is registered with PROSPERO: CRD42022343489