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The FLAVR SAVR TM tomato was developed through the use of antisense RNA to regulate the expression of the enzyme polygalacturonase (PG) in ripening tomato fruit . This enzyme is one of the most abundant proteins in ripe tomato fruit and has long been thought to be responsible for softening in ripe tomatoes . The FLAVR SAVR TM tomato is the first genetically engineered whole food to be sold in commerce . The history of the development of this product is discussed beginning with the results of the original anti sense work (including conclusions regarding the role of PG in ripe tomatoes) and will be followed by a description of the regulatory and food safety assessment . Finally, the development of an operating business to produce, market and distribute a genetically engineered whole food product is discussed .

Previous studies have shown that obese surgical patients have a greater volume of acidic stomach contents than lean patients, despite a routine preoperative fast. We have reexamined this issue and found that among otherwise healthy, fasted, obese surgical patients, there is a lower incidence of combined high-volume, low-pH stomach contents compared with lean patients.