To study the efficacy of lopinavir-ritonavir and hydroxychloroquine in critically ill patients with coronavirus disease 2019 .Methods: Critically ill adults with COVID-19 were randomized to receive lopinavir-ritonavir, hydroxychloroquine, combination therapy of lopinavir-ritonavir and hydroxychloroquine or no antiviral therapy (control). The primary endpoint was an ordinal scale of organ support-free days. Analyses used a Bayesian cumulative logistic model and expressed treatment effects as an adjusted odds ratio (OR) where an OR > 1 is favorable. Results:We randomized 694 patients to receive lopinavir-ritonavir (n = 255), hydroxychloroquine (n = 50), combination therapy (n = 27) or control (n = 362). The median organ support-free days among patients in lopinavir-ritonavir, hydroxychloroquine, and combination therapy groups was 4 (-1 to 15), 0 (-1 to 9) and-1 (-1 to 7), respectively,

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This article presents results from over 100 experimental autoclave curing fiber‐glass‐epoxy composite laminate curing runs. The primary objective was to verify shrinking horizon model predictive control—SHMPC—for thickness and void content control, using readily available secondary measurements. The secondary objective was to present and analyze the extensive experimental results obtained through this verification. Seven series of curing runs (16 per series) were performed, with cure settings governed by partial‐ or full‐factorial orthogonal array based design of experiments. Through t‐tests and two‐way analysis of variance, it was found that pressure magnitude had the largest influence on laminate thickness and void content, while first hold duration/temperature, pressure application duration, and run delay influenced void content more than thickness. Thinner laminates with lesser void contents resulted from pressure application before the second temperature ramp. Prepreg age also affected thickness and void content. Photomicrographs revealed not one large void, but void clusters. Interrupted autoclave cure cycles revealed that significant laminate thickness reduction occurred during all curing cycle stages. The percentage of resin weight loss through laminate sides increased with pressure magnitude and application duration. Ten test curing runs indicated that SHMPC met difficult thickness targets while minimizing void content.