Dental nurses and practitioners are at high risk of exposure to COVID-19 due to physical proximity and exposure to body fluids during treatment. Dental practices have implemented multiple protective protocols to decrease COVID-19 transmission; however, it is difficult to evaluate how effective these measures are, as there is limited data on COVID-19 in dental practices. To evaluate COVID-19 infection rates among dentists, dental staff, and patients in different countries through an online survey, with a primary focus on South Africa (SA). Cross-sectional online survey. One hundred fifty-four participants from 52 countries answered the survey, 48.6% (n=561) from SA. COVID-19 infections were reported in 18.2% (n=210) of dental practices. Only 1.1% regarded the practice as the source of infection for dentists and staff who got infected. In total, 13.9% (n=160) treated COVID-19 patients. SA presented a higher infection rate (19% vs 13%, p=0.04) and more frequent treatment of COVID-19 patients than the other countries combined (17% vs 11%, p=0.006). These findings support the need to maintain strict infection control measures to decrease transmission of SARSCoV-2 during the delivery of oral care.