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Purpose The aim of this review is to systematically review randomized controlled trials on lifestyle interventions on PCa patients undergoing androgen deprivation therapy. Methods A literature search was conducted using the electronic databases Medline and PubMed. To be eligible, studies had to be randomized controlled trials (RCTs) that focused on side effects of ADT and lifestyle interventions to reduce side effects for men undergoing ADT with PCa. Lifestyle interventions were defined as interventions that included any dietary or behavioral components. Results Twenty-nine trials were included. Most of them focused on exercise interventions, while some investigated the effect of dietary or behavioral interventions. The effect of different lifestyle influencing modalities aimed to improve on the adverse effects of ADT varied greatly. Conclusions It is not possible to draw one conclusion on the effect of exercise-based interventions, but noted on several adverse effects of ADT improvement. Further studies are necessary to develop personalized lifestyle interventions in order to mitigate the adverse effects.

Impaired wound healing is the result of the interplay between patient-related factors, wound-related factors, skill and knowledge of the healthcare professional and resources and treatment-related factors. The study of wound-related factors learns us that healing is a very complex biologic process. Both 'seed' (differentiated and stem cells) and 'soil' (e.g. cytokines/chemokines, growth factors, matrix components) are essential for effective wound healing. Tissue engineering for chronic wounds has the potential to improve healing by providing an 'ideal' combination of cells and their local microenviroment. In this contribution we discuss new treatment strategies to improve wound-related factors by biomaterials, skin substitutes and stem cell-based therapies.

We report a case of a successful treatment of post prostatectomy urinary stress incontinence with bulk injections after failed primary treatment with a sling. Keywords: Incontinence; Sling; Bulking agent; Therapy; Post-prostatectomy Case presentation A 70 year-old man was referred to the Urologen Kliniek Vleuten, with complaints of persistent stress urinary incontinence (SUI). His past medical history includes an open radical prostatectomy for a pT2cNxMx Gleason 6 adenocarcinoma of the prostate, with an initial PSA of 6.6 July 2011. Two years after prostatectomy the patient still complained of mild SUI, despite extensive pelvic floor physiotherapy. To treat the incontinence, an Argus sling was implanted in 2013. Nevertheless, the patient still complained of stress urinary incontinence after this procedure.

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