Learning behind the screen was implemented here in the Philippines since Covid-19 hit all over the world. For almost two years that people are suffering and struggling with what happened these days. Due to this pandemic, Notre Dame of Midsayap College implemented learning behind the screen. This paper is all about the effects of learning behind the screen on the learning performance of students in Microbiology and Parasitology subjects. The researchers used pre-test – post-test and interview research design. The researchers wanted to find out the learning performance through standardized pre-test and post-test which were administered in asynchronous and synchronous classes. An in-depth interview was also performed which involved both direct questioning and probing questions. Findings have revealed that the mean score of the students increased from asynchronous to synchronous class which was a teacher factor because there was communication between the teacher and students. Results also showed that the respondents had difficulties in answering the pre-test and post-test in asynchronous class, while, it is easy for them to answer the post-test during synchronous class. After a careful analysis of the responses of the respondents, the researchers concluded that the students taking Microbiology and Parasitology subjects could learn more during synchronous class or with the guidance of the subject teacher.