Much of the press on the pandemic has been focused on urban environments where the virus was quick to spread and the numbers of cases are high. Beyond the greater risk for COVID-19-related health complications, rural populations are particularly susceptible to disruptions in the economic infrastructure of their communities. This study explores the impacts of COVID-19 on rural communities and the responses of nonprofit and other community infrastructures. Using a strengths-based approach and mixedmethods design, this qualitative research asked rural residents and nonprofit leaders about their needs, challenges, and assets as a result of COVID-19. Themes relative to access, interdependence, and community emerged from a priori categories. The research offers implications for both nonprofit education and rural nonprofit leadership.