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Solutions to global problems such as disease detection and control, terrorism, immigration and border control, and illicit drug trafficking require sharing and coordinating information and collaboration among government agencies within a country and across national boundaries. This paper presents an approach to achieve information sharing, event notification, enforcement of policies, constraints, regulations, security and privacy rules, and process coordination. The proposed system, designed in collaboration with stakeholders and end users in two Latin American countries, achieves the desired capabilities by integrating a distributed query processor (DQP) that provides form-based and conversational user interfaces, a language translation system, an event server for event filtering and notification, and an event-trigger-rule server. The Web-services infrastructure is used to achieve the interoperation of these heterogeneous component systems. A prototype of the integrated transnational information system is described.