Background: In India, prevalence data from dermatology clinic in a teaching hospital in Varanasi reported acne in 50.6% of boys and 38.13% of girls in the age group 12-17 years. Though it is considered to be merely a cosmetic problem, it is associated with considerable psychological impairment which is comparable with certain chronic diseases. Acne patients are prone to low self-esteem, low self-confidence and social dysfunction which may lead to anxiety, depression, obsessive compulsiveness and sometimes suicidal ideation. Acne affects the functional abilities of individuals and patients have higher rate of unemployment when compared to those without acne. Acne also may have negative impact on personal relationships, sports activities and employment opportunities in teens and young adults. The management of acne must take into account the impact of acne on the patient's quality of life. So the present study was carried out to determine the impact of acne and its clinical severity on quality of life among patients of different grades of acne patients in various age groups. Methods: The current cross sectional study was conducted in Patients diagnosed as acne vulgaris attending OPD of PCMS and RC Bhopal (India) in department of dermatology for a period of 2 year. (November 2012 -October 2014. 300 patients attending the Dermatology OPD with diagnosis of acne vulgaris were taken for the study. Patients aged 16 -35 years were included in our study. A detailed history was taken after obtaining consent from all the participants of study. Cardiff Acne disability index (CADI) and Dermatology life quality index (DLQI) were administered on patients to determine the impact of acne vulgaris on quality of life (QOL). Data was analyzed to compare the quality of life indices (CADI and DLQI) for duration and severity of acne. Results: Mean age of study population was 20.69 years. There was a male preponderance with ratio of 1.04:1 (M:F). According to this study 49% of patients had acne vulgaris for less than 1year. In present study maximum number 63.7% of patients presented with lesions over face followed by 14.7% of patients having lesions over face and back. According to DLQI scores of acne showed no effect in 4.3% of the patients, small effect in 26.3% of the patients, moderate effect in 38.7% of patients, very large effect in 29% of patients and extremely large effects on 1.7% of patients. According to CADI scores of acne showed low effect in 31.3% of the patients, majority had medium effect in 56.7% of patients and high effect was seen on 12 % of patients. Conclusions: Overall our study showed that quality of life is significantly impaired in patients of severe acne vulgaris. Use of these simple QOL measures as a part of integral clinical strategy will improve the outcome.