Introduction: Analysis of multimodal medical images often requires the selection of one or many anatomical regions of interest (ROIs) for extraction of useful statistics. This task can prove laborious when a manual approach is used. We have previously developed a user-friendly software tool for image-to-image translation using deep learning. Therefore, we present herein an update to the DeepImageTranslator V2 software with the addition of a tool for multimodal medical image segmentation analysis (hereby referred to as the MMMISA). Methods: The MMMISA was implemented using the Tkinter library; backend computations were implemented using the Pydicom, Numpy, and OpenCV libraries. We tested our software using 4188 slices from whole-body axial 2-deoxy-2-[18F]-fluoroglucose-position emission tomography/ computed tomography scans ([¹⁸F]-FDG-PET/CT) of 10 patients from the American College of Radiology Imaging Network-Head and Neck Squamous Cell Carcinoma (ACRIN-HNSCC) database. Using the deep learning software DeepImageTranslator, a model was trained with 36 randomly selected CT slices and manually labelled semantic segmentation maps. Utilizing the trained model, all the CT scans of the 10 HNSCC patients were segmented with high accuracy. Segmentation maps generated using the deep convolutional network were then used to measure organ specific [¹⁸F]-FDG uptake. We also compared measurements performed using the MMMISA and those made with manually selected ROIs. Results: The MMMISA is a tool that allows user to select ROIs based on deep learning-generated segmentation maps and to compute accurate statistics for these ROIs based on coregistered multimodal images. We found that organ-specific [¹⁸F]-FDG uptake measured using multiple manually selected ROIs is concordant with whole-tissue measurements made with segmentation maps using the MMMISA tool. Doi: 10.28991/HIJ-2022-03-03-07 Full Text: PDF

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