Abstract. The Infrared Atmospheric Sounding Interferometer (IASI) onboard the MetOp satellite measures carbon monoxide (CO) on a global scale, twice a day. CO total columns and vertical profiles are retrieved in near real time from the nadir radiance spectra measured by the instrument in the thermal infrared (TIR) spectral range. This paper describes the measurement vertical sensitivity and provides a first assessment of the capabilities of IASI to measure CO distributions. On the global scale, 0.8 to 2.4 independent pieces of information are available for the retrieval. At mid latitudes, the information ranges between 1.5 and 2, which enables the lower and upper troposphere to be distinguished, especially when thermal contrast is significant. Northern Hemisphere and in the equatorial region. However when strong CO concentrations are present, such as during fire events, these discrepancies can climb as high as 17%. Instrument specifications of IASI versus other missions are also discussed.