It has been used in various ailments and diseases like-control of bleeding from wounds and cuts, expediting wound healing, relief of common headache, faster healing, prevention of gastric ulcer and also for decreasing inflammation.

Objective: Depression is an affective disorder characterized by a change in mood, lack of confidence, lack of interest in surroundings and many natural products that have been tried to treat the disease. The study was aimed to evaluate and compare the antidepressant activity of methanol leave extract of SapindusemarginatusVahl. (MESE) and Acoruscalamus Linn. (MEAC) in experimental models in albino mice. Methods: Methanol Extracts of the plants were prepared by soxhlet extraction method. Forced swimming test (FST) and Tail suspension test (TST) models were chosen to evaluate antidepressant activity.Albino mice were selected and divided into six groups of six animals for each experimental model. Group I received 1% gum acacia in distilled water (DW) at a dose of 1 ml/100 g orally. Group II received sertraline-10 mg/kg orally. Group III and IV were administered 200 and 400 mg/kg of MESE respectively. Group V and VI were treated with 200 and 400 mg/kg of MEAC, respectively. Results: Methanol extracts of Sapindusemarginatus and Acoruscalamus at the two different doses of 200 and 400 mg/kg demonstrated a significant decrease in immobility time when compared with the control in both animal models. The extracts at the higher dose of 400 mg/kg revealed a significant reduction in immobility time compared to 200 mg/kg of the same extract. Conclusion: The results suggest that the methanol extracts of SapindusemarginatusVahl. andAcoruscalamus Linn. possessthe anticonvulsant activityand justify their use in folk medicine.

Objective: The study was aimed to evaluate and compare the anticonvulsant activity of aqueous leave extract of Portulaca oleracea Linn. and Eupatorium brimanicum DC in MES model in albino mice. Methods: Aqueous Extracts were prepared by the soxhlet extraction method. MES model was chosen to evaluate anticonvulsant activity. 36 albino mice were selected and divided into 6 groups for this model. Group I received 2% gum acacia 1 ml/100 g orally. Group II received phenytoin-20 mg/kg orally. Group III and IV received 200 and 400 mg/kg of Portulaca oleracea Linn. Respectively. Group V and VI received 200 and 400 mg/kg of Eupatorium brimanicum DC respectively. Results: The extracts didn’t show any toxicity and significantly reduced hind limb tonic extension (HLTE) duration in MES model (50 mA, 0.2 sec) at higher doses. Conclusion: The results suggest Portulaca oleracea Linn. and Eupatorium brimanicum DC extract possess anticonvulsant activity and justify their use in folk medicine.

Background and aim: Self-medication with antibiotics is one of the growing issues in developing countries. Irrational use of antibiotics leads to development of resistance. Antibiotic resistance is a growing threat in management of infectious disease which leads to morbidity and mortality. Our study is to assess the self-medication pattern of antibiotic among the people of Imphal West district of Manipur. Materials and methods: A cross-sectional study was conducted on 1980 randomly selected people from populations of Manipur during September 2020. Data was collected using modified pre-structured questionnaire. Using SPSS software version 21, descriptive data analysis was done and expressed in frequencies and percentages. Result: In the study, female participants were more than male participants and majority were from the age group 18-30 years, educated and low-income group. Azithromycin was the most commonly used antibiotics followed by amoxicillin and clavulanic acid combination. Majority of them obtained the antibiotics from local pharmacies and was mainly recommended by the pharmacists. Only 16.92% of them faced mild adverse reaction. Around 65.04% of the participant considered that self-medication with antibiotics is not a safe practice. Conclusion: This study showed that antibiotics were easily accessible and many people were not aware about the antibiotic usage and risk of developing its resistance in Imphal West. Higher authorities need to enlighten the public about the rational use of antibiotics and the dangerous effects of self-medication to overcome the antibiotic resistance.

In the present study, the anti-inflammatory activity of aqueous extract of Portulaca oleracea (POE 200, 400 and 600mg/kg) was studied using carrageenan induced paw oedema in albino rats. The mean increase in paw volume was recorded. POE produced significant (p<,0.01) anti-inflammatory activity when compared to the control. The anti-inflammatory action of POEcan be attributed to its flavonoid contents which are known to act through inhibition of prostaglandin biosynthesis. However, the test drug at maximum dose (600mg/kg) was found to be less effective than the standard drug, aspirin (100mg/Kg).