Highlights d PPARg S112 phosphorylation is crucial for its K107 SUMOylation and IL-10 suppression d PIAS2 is the specific E3 SUMOligase causing CL-mediated PPARg K107 SUMOylation d JNK-MAPK is responsible for CL-mediated PPARg S112 phosphorylation d Repurposing a clinically used JNK inhibitor can improve survival in pneumonia
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