BACKGROUND Adipose tissue myringoplasty is a technique for closing small perforation in the tympanic membrane. It is a safe and cost-effective technique and can be performed in day-care settings. Objective-To determine the effectiveness of tisssue myringoplasty in comparison to that of the conventional myringoplasty. MATERIALS & METHODS A non-randomized controlled trial was taken up in the Department of Otorhinolaryngology, JNIMS during the period Aug 2015-July 2017. Uncomplicated patients having small perforations attending the department were the study subjects. Tissue myringoplasty and the conventional myringoplasty were performed to equal number of eligible patients on alternate case basis. The studysubjects were then followed up for a minimum period of three months to assess the outcome. RESULTS Success rate by conventional myringoplasty was found to be 93.33% whereas for tissue myringoplasty it was 84.44%. CONCLUSION Although the effectiveness of tissue myringoplasty was slightly lower than that of the conventional technique, taking into consideration the simplicity, safety and cost-effectiveness associated with it, tissue myringoplasty can be considered the procedure of choice in patients with suitable tympanic membrane perforation.