Introduction:The primary objective of this study was to identify the percentage of oxaliplatin-induced vascular pain during administration in Iraqi patients. The secondary objective was to identify the risk factors for vascular pain. Methods: This is a cross-sectional observational study carried out at the Al-Andalus private hospital for cancer patients, Baghdad, Iraq. The study included 101 patients, diagnosed with one of the following cancers: colon, pancreatic, stomach, and rectal cancer, ranging from 18 to 80 years, and receiving oxaliplatin peripheral venous infusion. Data collected included: age, gender, diagnosis, history of chronic disease, treatment protocol, degree of pain severity, cancer stage, history of previous vascular pain, number of cycles, the incidence of vascular pain, oxaliplatin dose. Results: Sixty-two patients out of 101 patients had experienced vascular pain during oxaliplatin peripheral venous infusion, representing about (61.4 %). History of diabetes mellitus was significantly associated with vascular pain induction (OR=1.59, [CI: 1.07 -2.39]). The age group from 40-60 years old was significantly associated with 59 % higher odds of vascular pain (OR=1.59, CI: 1.07 -2.39) than other age groups. Female patients were significantly associated with 59 % higher odds of vascular pain (OR=1.59, CI: 1.07 -2.39) than males. Conclusion:The results of this study indicate that history of diabetes mellitus, the age group from 40-60 years old, and female gender are risk factors for oxaliplatin-induced vascular pain in patients with GI malignancy. These findings could be useful to assess the risk of vascular pain in clinical settings.