Serous endometrial intraepithelial carcinoma (SEIC) is a rare but highly aggressive form of uterine endometrial cancer. We present a case of a premenopausal 42-year-old patient who presented with copious vaginal bleeding without a specific medical history. A total abdominal hysterectomy was performed. Pathologic results showed SEIC. We report this case and include a brief literature review.

Peritoneal dissemination is a predominant pattern of metastasis in patients with advanced ovarian cancer. Despite recent progress in the management strategy, peritoneal dissemination remains a determinant of poor ovarian cancer prognosis. Using various histological types of patient‐derived ovarian cancer organoids, the roles of the apicobasal polarity of ovarian cancer cell clusters in peritoneal dissemination were studied. First, it was found that both ovarian cancer tissues and ovarian organoids showed apicobasal polarity, where zonula occludens‐1 (ZO‐1) and integrin beta 4 (ITGB4) served as markers for apical and basal sides, respectively. The organoids in suspension culture, as a model of cancer cell cluster floating in ascites, showed apical‐out/basal‐in polarity status, while once embedded in extracellular matrix (ECM), the organoids switched their polarity to apical‐in/basal‐out. This polarity switch was accompanied by the SRC kinase family (SFK) phosphorylation and was inhibited by SFK inhibitors. SFK inhibitors abrogated the adherence of the organoids onto the ECM‐coated plastic surface. When the organoids were seeded on a mesothelial cell layer, they cleared and invaded mesothelial cells. In vivo, dasatinib, an SFK inhibitor, suppressed peritoneal dissemination of ovarian cancer organoids in immunodeficient mice. These results suggest SFK‐mediated polarity switching is involved in peritoneal metastasis. Polarity switching would be a potential therapeutic target for suppressing peritoneal dissemination in ovarian cancer.

Objectives: To investigate inflammatory responses after laparoscopic radical hysterectomy in Japanese women with early-stage cervical cancer.Methods: Clinical data of patients with early-stage cervical cancer treated with laparoscopic radical hysterectomy, between January 2013 and June 2018, were collected and retrospectively reviewed. The patients were classified into 2 groups: normal (patients without postoperative complications) and complication (patients who experienced postoperative complications) groups. Their postoperative leukocyte/neutrophil counts and C-reactive protein (CRP) levels (inflammatory markers) were evaluated. Finally, we investigated the clinical utilities of the inflammatory markers to predict postoperative complications using receiver-operating characteristic (ROC) analysis.Results: Fifty-three Japanese women underwent laparoscopic radical hysterectomy for early-stage cervical cancer.Postoperative complications occurred in 10 patients (18.9%). In the normal group, inflammatory markers peaked on postoperative day (POD) 1 and declined thereafter. Similarly, in the complication group, inflammatory markers peaked on POD 1 and declined on POD 3. However, they increased again thereafter, resulted in peaks on PODs 9-15. When the 2 groups were compared, inflammatory markers were significantly higher in the complication group than in the normal group. A leukocyte count >7280/μL, neutrophil count >6030/μL, or CRP level >0.4 mg/dL on POD 6 exhibited high sensitivities and specificities for the prediction of postoperative complications: leukocyte count (83.3%, 87.5%), neutrophil count (83.3%, 87.5%), or CRP level (100%, 56.3%), respectively. The negative predictive values of these markers were 93%, 93%, and 100%, respectively. Conclusion:Inflammatory responses after laparoscopic radical hysterectomy in Japanese women with early-stage cervical cancer were evaluated. Leukocyte/neutrophil counts or CRP levels on POD 6 are useful to predict postoperative complications, allowing for safe and early discharge.