BACKGROUND The incidence rate for cancer reflects the number of new cases occurring in a specific population during a year, expressed as the number of cancer diagnosis per 10,000 people. Cancer is globally a major cause of death and morbidity and is currently witnessing an exponential increase in the number of malignancies. The present study was conducted to assess the knowledge regarding self-care among patients receiving chemotherapy, to evaluate the effectiveness of information booklet regarding selfcare among patients receiving chemotherapy and to find out the association between knowledge score regarding self-care among patients receiving chemotherapy in selected hospitals. METHODS An experimental study was undertaken on 60 purposively selected patients receiving chemotherapy in selected hospitals of Wardha and Nagpur district. One group pretest post-test research design was used in the study. Data was collected by using structured questionnaire during the month of December 2019. The duration of study was for 5 months from October 2019 to February 2020. RESULTS The findings of the study show that 33.33 % patients had average knowledge score, 61.67 % patients had good knowledge score and 5 % patients had very good knowledge score in pre-test. Minimum knowledge score was 8 in pre-test and maximum knowledge score was 23 in pre-test. Mean knowledge score in pre-test was 15.53 ± 2.98 and mean percentage of knowledge score in pre-test was 44.38 ± 8.52. 11.67 % of patients had good knowledge score, 81.67 % of patients had very good knowledge score and 6.67 % of patients had excellent knowledge score in post-test. Minimum knowledge score was 20 in post-test and maximum knowledge score was 30 in the post-test. Mean knowledge score in pre-test was 24.61 ± 2.53 and mean percentage of knowledge score in post-test was 70.33 ± 7.25. It indicates that information booklet is effective in improving knowledge of patients receiving chemotherapy. CONCLUSIONS Patients receiving chemotherapy have average knowledge regarding chemotherapy self-care. After providing information booklet, there was a very significant increase in the knowledge. The combined ‘t’ test was assessed in all hospitals for value of pretest knowledge and post-test knowledge score. Thus, it is concluded that the booklet on chemotherapy self-care is effective in improving the knowledge of patients receiving chemotherapy. KEY WORDS Cancer, Chemotherapy, Effectiveness, Self-Care