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Background: There is conflicting data regarding the impact of obesity on morbidity and mortality in patients undergoing isolated coronary artery bypass grafting (CABG). Methods and Results:Retrospective cohort analysis of patients who underwent CABG from January 1, 1995, through July 31, 2010 was performed. Patients were classified as obese or non-obese (body mass index ≥30.0 kg/m 2 and <30.0 kg/m 2 , respectively). The primary outcome was in-hospital mortality. Secondary outcomes included postoperative respiratory failure, postoperative stroke, postoperative myocardial infarction, sternal and leg wound infections, postoperative atrial fibrillation, postoperative ventricular tachycardia, postoperative renal failure and length of hospital stay. Propensity-matched stepwise multivariable logistic regression was performed. Of 13,115 patients, 4,619 (35.2%) were obese. In the propensity-matched logistic regression models (n=8,442), obesity was not associated with postoperative mortality (odds ratio =1.13, 95% confidence interval 0.86-1.48). However, obesity was associated with postoperative respiratory failure, postoperative renal insufficiency, sternal wound infection, and leg wound infection. Obesity was also associated with a decreased risk of postoperative bleeding and re-operation from bleeding. Conclusions:Obesity was associated with an increased risk of postoperative respiratory failure, postoperative renal failure, and surgical site infections. However, obesity was not associated with in-hospital mortality in patients undergoing CABG. (Circ J 2011; 75: 1378 - 1385

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Statin therapy has been associated with improved outcomes in patients with infections. Our aim was to determine whether preoperative statin therapy is associated with a decrease in the incidence of infections after coronary artery bypass grafting (CABG) surgery. Methods: We conducted a retrospective cohort study of 6,253 patients undergoing isolated CABG from January 1, 2000 to December 31, 2010 (3,869 receiving statins and 2,384 not receiving statins). Primary outcome was the development of any postoperative infection (composite of deep sternal wound infection, leg harvest-site infection, pneumonia and sepsis) after CABG. Secondary outcome was the effect of statins on incidence of each aforementioned infection individually. Logistic regression analyses were performed. Results (Table): Incidence of any postoperative infection in patients who received statins preoperatively was 6.5% (250 of 3,869) compared to 8.3% (198 of 2,384) in controls. In fully adjusted models, preoperative statin therapy was independently associated with a significant reduction in the development of any postoperative infection. Among individual infections, preoperative statin therapy was associated with a reduced incidence of sternal wound and leg harvest site infections. An association with a reduced incidence of pneumonia and sepsis was not found. Conclusions: Preoperative statin use is associated with a decreased incidence of sternal wound infections and leg harvest site infections after CABG