Background: Self-medication is the use of medicinal products by the consumer which is not prescribed by the physician or doctor. Self-medication practice (SMP) is widely adopted by the common people of developing countries like Bangladesh. Study Design: Cross-sectional study. Aim & Objective: This study was conducted to learn about the knowledge and awareness level and to evaluate the practice and attitude towards self-medication among the common people of Bangladesh. Method: Primary data was collected by conducting an online survey with a well-constructed questionnaire. Data collection was carried out from May 2021 to June 2021. The subjects were minimum 15 years of age. From 35 districts of Bangladesh, total 322 people of different age groups, education levels, economic classes participated in the survey. Result: 71% (229) of the respondents were 21-25 years of age. 66% were undergraduate students. Most of them were from middle class society and well-educated. 80% of the population said that they had purchased or taken medicines without any prescription. 57% of them told they do not consider self-medication as a very safe practice although, 87% of the population had practiced self-medication at least once in the preceding year. Antipyretics (212), Analgesics (165), Drugs for Cold/Cough (197) and Anti-ulcer/Antacids (140) were the majority categories of medicines that were used mostly for self-medication. Nearly all (311) of them collects SMP medicine from Pharmacy shops. Previous prescription (146), Advice from family or friends (165) and Internet or other media (113) were their common sources of information for their self-medication practice. Conclusion: Self-medication practice is highly prevalent in Bangladesh. People are not aware enough about possible negative outcomes of it. Therefore, the regulatory laws should be implemented more strictly regarding buying and selling medicines
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