Diabetes mellitus (DM) and hepatic steatosis are two of the most common metabolic syndromes that affect the health of people globally. Empagliflozin (EMPA) is a promising drug of choice for the diabetic population. Recent studies have shown its beneficial effects not only on diabetic patients but also on patients suffering from cardiac, hepatic, neurological, or pancreatic anomalies. In this paper, we systematically searched electronic databases to compile literature that focuses on EMPA’s effect on the prediabetic population, diabetic population, and hepatic lipid metabolism. We focus on the mechanism of EMPA, specifically by which it increases insulin sensitivity and fat browning and reduces fat accumulation. Overall, we hypothesized that by its effect on weight loss and reducing inflammatory markers and insulin resistance (IR), EMPA decreases the rate of prediabetes to diabetes conversion. We concluded that by improving hepatic and serum triglyceride, decreasing visceral fat, and its positive impact on hepatic steatosis, the drug improves hepatic lipid metabolism. Further research should be done on this matter.

Background: The cardiac operative procedure has a significant relationship with acute onset of pain. After cardiac surgery, pain has been managed with the help of opiate analgesics. Objective: To analyze the adverse effects of postoperative multimodal analgesia after cardiac surgery concerning the physical and specific biochemical parameters of undergoing surgery patients. Materials & Methods: It was a single-center, prospective study where patients were approached on the day before their cardiac surgery. A total of 120 post-cardiac operative surgery patients at Khwaja Yunus Ali Medical College Hospital, Sirajganj were included for this study purpose. Results: In first group, three types of analgesia were used in 60 patients and in second group, five types of analgesia were used in another 60 patients. About 76.7% were male and mean age was 45.73 (± 11.3) years. Fentanyl was used for all patients followed by paracetamol (96.7%), diclofenac (83.3%), tramadol (16.7%), and pethidine (3.3%). Drug-induced nausea and vomiting were found in 76.7%and 66.7% patients respectively followed by drowsiness (36.7%) and vertigo (20.0%). Conclusion: In patients undergoing cardiac surgery, a multimodal regimen offered better analgesia. Furthermore, nausea and vomiting complaints were reduced significantly in the multimodal group. KYAMC Journal Vol. 13, No. 02, July 2022: 94-97

Electrolyte abnormalities are common in acute stroke patients and have a substantial impact on the course and prognosis of the disease. Electrolyte imbalances such as hyponatremia, hypokalemia, hypocalcemia, hypomagnesemia, and phosphate abnormalities are frequently seen in this patient population. The incidence, root causes, and medical ramifications of electrolyte abnormalities in acute stroke patients are investigated in this comprehensive study. According to our research, hyponatremia is the most prevalent electrolyte imbalance. The most common reason for hyponatremia in stroke patients is the syndrome of inappropriate antidiuretic hormone secretion (SIADH). Higher mortality rates, longer hospital admissions, and less favorable functional outcomes are all linked to hyponatremia. Acute stroke patients also typically experience hypokalemia, which affects the severity of the stroke and the recovery of functional abilities. The review furthermore emphasizes the incidence and clinical consequences of hypercalcemia, hypomagnesemia, hypophosphatemia, and hypocalcemia in patients with acute stroke. The results highlight the significance of early electrolyte imbalance detection and treatment in acute stroke patients. To better comprehend therapeutic approaches, evaluate their influence on stroke outcomes, and analyze prognostic implications, more research is required.