Introduction: Spinal tubercular infection is the most common and dangerous form of skeletal tuberculosis. Transpedicular instrumentation systems have distinct advantages such as rigid segmental fixation, stabilization of the three column of the spine, least failure at bone metal interface, early post-operative mobilization with efficient nursing care and least complications in the management of tuberculosis of the thoraco-lumbar spine. Objectives was to evaluate the outcome of decompression and transpedicular screw fixation in the management of tuberculosis of the thoracolumbar spine. Materials and Methods: An observational follow-up study. A total no. of 21 patients aged between 19-72 years and both sexes (Male-9, Female-12) was included in the study. Patients diagnosed as tuberculosis of the thoraco-lumbar spine were operated by direct decompression, transpedicular screw fixation and fusion with bone graft and mesh cage in some cases. First follow-up at 1 month after operation and thereafter at 3 and 6 months follow-up was done. Results: This study shows mean±SD age was 40±11.29 years. 57.1% were female and 42.9% were male. Lesion 66.7% were dorsal, 19.0% were lumbar and 14.3% were dorsolumbar. 42.86% were ASIA grade C, 33.33% were ASIA grade D, 9.52% were both ASIA grade B & E and 4.76% were ASIA grade A in preoperative stage. On the other hand in postoperative 61.90% were ASIA grade E, 33.33% were ASIA grade D and 4.76% were ASIA grade B. The difference was statistically significant (P<0.001). Four-fifths (80.95) of the patients had excellent outcome followed by 14.29% good outcome, 4.76% fair and 0% poor outcome. Conclusions: Posterior approach is a minimum surgical intervention that encourages neurological recovery. Medicine Today 2020 Vol.32(2): 104-111

Pesticides have been used to treat agricultural lands since ancient times. The effects of an organophosphate (OP) and pyrethroid combination on the haemato-biochemical and histological functions of male albino rats were investigated. Male albino rats (total 18 rats, 12 are treated and 6 are control) were dermally treated with two organophosphate and pyrethroid combinations for 8 weeks (chlorpyrifos, chlorpyrifos-methyl, and lambda-cyhalothrin). We also looked at organ weights, haematological and histological changes, and clinical symptoms. Except for RBCs, total protein, and haemoglobin, all haematological measures rose in treated rats after 8 weeks. After 4 weeks, Runsave and Lambaphos treatments had RBC counts of 5.02 and 5.15 106/mm3, respectively, compared to 6.1 106/mm3 in the control group. Haemoglobin values for Runsave, Lambaphos, chlorpyrifos, chlorpyrifosmethyl, and lambda-cyhalothrin were 13.53, 14.27, 14.60, 15.03, and 15.27 g/100 ml after toxicant administration, compared to 16.53 in the control. Haematological parameters change correlated positively with exposure time. A histological examination on liver and kidney found that Runsavetreated rats had an uneven structure, severely congested blood arteries, necrotic areas, fatty liver, pyknotic nuclei, and cytoplasmic vacuolation in hepatic cells. Lambaphos-treated liver shows haemolysis, cytoplasmic vacuolation, pyknotic nuclei, and partial structural disruption. Bowman's capsule, glomeruli, and proximal tubule are normal in the control kidney. Runsave had abnormal renal anatomy. Lambaphos kidneys are asymmetrical. This study demonstrated that albino rats subjected to an insecticide mixture of organophosphate and pyrethroid had significant histological and haematobiochemical changes compared to the control group. Vol. 9, No. 2, August 2022: 185-200