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General control non-depressible 5 (GCN5) or lysine acetyltransferase 2A (KAT2A) is one of the most highly studied histone acetyltransferases. It acts as both histone acetyltransferase (HAT) and lysine acetyltransferase (KAT). As an HAT it plays a pivotal role in the epigenetic landscape and chromatin modification. Besides, GCN5 regulates a wide range of biological events such as gene regulation, cellular proliferation, metabolism and inflammation. Imbalance in the GCN5 activity has been reported in many disorders such as cancer, metabolic disorders, autoimmune disorders and neurological disorders. Therefore, unravelling the role of GCN5 in different diseases progression is a prerequisite for both understanding and developing novel therapeutic agents of these diseases. In this review, we have discussed the structural features, the biological function of GCN5 and the mechanical link with the diseases associated with its imbalance. Moreover, the present GCN5 modulators and their limitations will be presented in a medicinal chemistry perspective.

Cognitive impairment is a state that affects thinking, communication, understanding, and memory, and is very common in various neurological disorders. Among many factors, age-related cognitive decline is an important area in mental health research. Research to find therapeutic medications or supplements to treat cognitive deficits and maintain cognitive health has been ongoing. Ginseng and its active components may have played a role in treating chronic disorders. Numerous preclinical studies have confirmed that ginseng and its active components such as ginsenosides, gintonin, and compound K are pharmacologically efficacious in different models of and are linked to cognitive impairment. Among their several roles, they act as an anti-neuroinflammatory and help fight against oxidative stress and modulate the cholinergic signal. These roles may be involved in enhancing cognition and attenuating impairment. There have been some clinical studies on the activity of ginseng in cognitive impairment, but many ginseng species and active compounds remain to be investigated. In addition, new formulations of active ginseng components such as nanoparticles and liposomes could be used for preclinical and clinical models of cognitive impairment. Here, we discuss the therapeutic potential of active ginseng components in cognitive impairment and their chemistry and pharmacokinetics and consider prospects for their delivery and clinical study with respect to cognitive impairment.

Abstract AbstractObjectiv Objectiv Objectiv Objectiv Objective: e: e:e: e: We aimed to find out frequency of self medication among university students of Chittagong, Bangladesh by using a cross sectional questionnaire based survey study. Method:Method: Method: Method: Method: For this study, 439 students selected from nine universities of Chittagong through non-probability convenience sampling. Results:Results: Results: Results: Results: Among the total respondents, 278(63.32%) respondents were males and 161(36.67%) respondents were females. The most important reasons for self medication were no need to visit doctor for minor illness 227(51.70%) and quick relief 161(36.67%). Among the total respondents, 229(52.16%) used same direction of self medication of him/her for their family. The highest proportion of respondents 229(52.16%) did not check expiry date of medicine when they buy medicine from retail pharmacy. There were several conditions they had used self medications and the greatest number of students used to treat headache 273(62.18%) and fever 199(45.33%). The data reveals that the highest proportion, 243(55.35%) students learned medications from doctor prescription provided to cure their previous illness. The greatest number of students 398(90.66%) chooses allopathic medicine among four different system of medicine. The respondents used different allopathic drugs used in self medications where greatest number 296(67.42%) used analgesics. Conclusion:Conclusion: Conclusion: Conclusion: Conclusion: This study revealed that the prevalence and practices of self-medication among the university student and the greater part of students had a poor knowledge about proper self-medication whereas the knowledge of the benefits and risks were not adequate. K K K K Ke e e e eyw yw yw yw ywor or or or ords: ds: ds: ds: ds: Frequency, self-medication, university students, questionnaire.