In Bangladesh, agriculture plays a major role in the national economy. In the drought prone Barind area in NW Bangladesh, cropping intensity has increased almost double since late eighties of last century (from 1985) because of the introduction of groundwater irrigation. Long-term behavior of groundwater table (GWT) in the drought prone Barind area has been studied using MAKESENS model in the wake of massive installation of tube-wells. The study reveals that the maximum and minimum depths to GWT during 1991-2010 show on average declining trend of 4.51 m and 4.73 m. The long-term prediction for the period of 2020-50 assuming the current rate of groundwater withdrawal is that the declining trend will be 1.16 to 1.59 and 1.07 to 1.82 times more for maximum and minimum groundwater depths respectively in comparison to the present. The rigorous exploitation of groundwater for irrigation, decreasing rainfall and surface geological attributes lead towards declining trend of GWT. This will hamper the country’s food security and ultimately threaten its socio-economic sustainability. So the appropriate strategies for the management of groundwater resource on a sustainable basis should be the priority for maintaining agricultural productivity.