Purpose Liver steatosis is a frequently reported condition in patients with inflammatory bowel disease (IBD). Different factors, both metabolic and IBD-associated, are believed to contribute to the pathogenesis. The aim of our study was to calculate the prevalence of liver steatosis and fibrosis in IBD patients and to evaluate which factors influence changes in steatosis and fibrosis during follow-up. Methods From June 2017 to February 2018, demographic and biochemical data was collected at baseline and after 6-12 months. Measured by transient elastography (FibroScan), liver steatosis was defined as Controlled Attenuation Parameter (CAP) ≥248 and fibrosis as liver stiffness value (Emed) ≥7.3 kPa. IBD disease activity was defined as C-reactive protein (CRP) ≥10 mg/l and/or fecal calprotectin (FCP) ≥150 μg/g. Univariate and multivariate regression analysis was performed; a p-value of ≤0.05 was considered significant. Results Eighty-two out of 112 patients were seen for follow-up; 56% were male. The mean age was 43 ± 16.0 years, and mean BMI was 25.1 ± 4.7 kg/m 2 . The prevalence of liver steatosis was 40% and of fibrosis was 20%. At baseline, 26 patients (32%) had an active episode of IBD. Using a multivariate analysis, disease activity at baseline was associated with an increase in liver steatosis (B = 37,, p = 0.027) and liver fibrosis (B = 1.2, 95% CI 0.27-2.14, p = 0.016) during follow-up. Conclusions This study confirms the relatively high prevalence of liver steatosis and fibrosis in IBD patients. We demonstrate that active IBD at baseline is associated with both an increase in liver steatosis and fibrosis during follow-up.

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Background The aim of this study was to analyze the value of the unadjusted CUSUM graph of liver surgical injury and discard rates in organ procurement in the Netherlands. Methods Unadjusted CUSUM graphs were plotted for surgical injury (C event) and discard rate (C2 event) from procured livers accepted for transplantation for each local procurement team compared with the total national cohort. The average incidence for each outcome was used as benchmark based on procurement quality forms (Sep 2010–Oct 2018). The data from the five Dutch procuring teams were blind‐coded. Results The C and C2 event rate were 17% and 1.9%, respectively (n = 1265). A total of 12 CUSUM charts were plotted for the national cohort and the five local teams. National CUSUM charts showed an overlapping “alarm signal.” This overlapping signal for both C and C2, albeit a different time period, was only found in one local team. The other CUSUM alarm signal went off for two separate local teams, but only for C events or C2 events respectively, and at different points in time. The other remaining CUSUM charts showed no alarm signaling. Conclusion The unadjusted CUSUM chart is a simple and effective monitoring tool in following performance quality of organ procurement for liver transplantation. Both national and local recorded CUSUMs are useful to see the implication of national and local effects on organ procurement injury. Both procurement injury and organ discard are equally important in this analysis and need to be separately CUSUM charted.

Background Increased liver steatosis is a frequently reported condition in patients with Inflammatory Bowel Disease (IBD). Different factors, both metabolic and IBD-associated, are believed to be contribute to the pathogenesis. The aim of our study was to calculate the prevalence of liver steatosis (LS) and fibrosis (LF) in IBD patients and evaluate which factors influence changes in steatosis and fibrosis during follow-up. Methods From June 2017 to February 2018, consecutive adult IBD patients were enrolled. Demographic and bio-chemical data were collected at baseline and after 6 to 12 months. The degree of LS and LF was assessed by transient elastography (Fibroscan). LS was defined as a Controlled Attenuation Parameter (CAP) ≥248, LF as a liver stiffness value (Emed) ≥7.3 kPa and IBD disease activity as C-reactive protein (CRP) ≥10 mg/l and/or fecal calprotectin (FCP) ≥150 μg/g. Changes in LS and LF were studied using ∆CAP and ∆Emed (follow-up minus baseline). An independent sample T-test was used to analyze the mean change in ∆CAP and ∆Emed. Univariate and multivariate linear regression analyses were performed, a P-value of ≤0.05 was considered significant. Results A total of 117 IBD patients were enrolled, of which 86 patients were also seen for follow-up. Of these 86 patients, 57% were male with a mean age of 43 (16.1) years. 48% of the patients suffered from Crohn’s disease. The mean Body Mass Index (BMI) was 25.0 (4.7) kg/m2 and 28 patients (33%) had an active episode of IBD at enrollment. The prevalence of LS at baseline was 39%, the prevalence of LF at baseline 13%. The mean change in ∆CAP was 22.44 (75.7) in patients with active disease at baseline and -34.1 (67.5) in patients in remission at baseline (p=0.001). The mean change in ∆Emed was 0.40 (1.9) in patients with active disease at baseline and -0.53 (2.7) in patients in remission at baseline (p=0.075).). Using a multivariate analysis, disease activity at baseline (B=37, 95%CI 6.38–67.61,P=0.018) and LS at baseline (B=-0.4, 95%CI -0.64 – -0.23,P=0.000) were associated with an increase in LS during follow-up. In univariate analyses, no factors associated with LF during follow-up were found. Conclusion Our study reveals a high prevalence of liver steatosis and liver fibrosis in IBD patients. Active IBD at baseline was associated with an increase in liver steatosis during follow up, but not with an increase in liver fibrosis.

Funding Acknowledgements Type of funding sources: None. Background  Transjugular intrahepatic portosystemic shunt (TIPS) is widely used to treat portal hypertension-related complications in patients with liver cirrhosis. Left ventricular diastolic dysfunction (LVDD) is associated with an increased risk of cardiac decompensation after TIPS, but its predictive value on long-term survival of TIPS candidates is currently unknown. In addition, the assessment of left atrial (LA) reservoir function, which recently emerged as sensitive marker of LVDD, has never been studied in this population. Purpose The main objectives were 1) to evaluate the association between LVDD, assessed according to the algorithm proposed by the Cirrhotic Cardiomyopathy Consortium (revised from the 2016 ASE/EACVI guidelines), and long-term survival in cirrhotic patients undergoing TIPS 2) to investigate the additive prognostic value of LA reservoir strain, measured by speckle-tracking echocardiography. Methods Patients with liver cirrhosis treated by TIPS were retrospectively evaluated. All subjects received an echocardiographic examination few weeks before the procedure. Threshold for LA reservoir strain (≤35%) to identify LA dysfunction was chosen based on the median value in the current population and on previously suggested cut-off value from the literature. The primary endpoint of the study was all-cause mortality. Results A total of 129 patients (61 ± 12 years; 61 % men) were included. According to the algorithm of the Cirrhotic Cardiomyopathy Consortium, 65 (50%) patients had normal diastolic function, 26 (20%) patients had grade 1 LVDD, 21 (16%) patients had grade 2 LVDD and 17 (13%) patients had indeterminate diastolic function. Additionally, LA dysfunction (LA reservoir strain ≤35%) was found in 67 (52%) patients. After a median follow-up of 36 months (interquartile range: 12-80), 65 (50%) patients died. Kaplan–Meier analysis for all-cause mortality at 4 years demonstrated a significant reduction in survival for more advanced grades of LVDD (log-rank p = 0.007) (Figure 1A). Furthermore, patients with LA dysfunction (LA reservoir strain ≤35%) had a higher cumulative event rate versus patients with preserved LA function (log-rank p = 0.001) (Figure 1B). Multivariable Cox regression analysis identified MELD (model for end-stage liver disease) score (Hazard ratio:1.06; p = 0.003), hemoglobin (Hazard ratio:0.74; p = 0.022) and LA reservoir strain (Hazard ratio:0.96; p = 0.005) as independent predictor of mortality (Figure 2). Excluding LA reservoir strain from the model, more advanced grades of LVDD (grade 2 and indeterminate function) became associated with the outcome. Of note, LA reservoir strain provided incremental prognostic value to the model including MELD score, hemoglobin and grades of LVDD (p = 0.004). Conclusions LA dysfunction, assessed by LA reservoir strain with speckle-tracking echocardiography, is an independent predictor of long-term mortality in in cirrhotic patients treated with TIPS. Abstract Figure.  Abstract Figure.