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Patients with hematologic malignancies or hematopoietic cell transplants who had febrile neutropenia demonstrated homogeneous calculated cefepime volumes and clearances. The population parameters presented in this study may aid in the calculation of patient-specific fT>MIC for similar patients.

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disease (GvHD) prophylaxis regimen. Survival analysis was calculated by Kaplan-Meier analysis and log-rank test was used to compare variables. Forty-three patients (21 of male) were enrolled; 22, 19 and 2 patients were diagnosed as ALL, AML and MDS, respectively. Twenty-three patients received TBI-regimen, and 26 patients received mother derived stem cell products. Most of the donors had 5/10 or 6/10 HLA-matched. The median CD34+ cell dose was 9.24 (2.06-21.8) cells £10 6 /kg. One patient died from disseminated adenoviral infection prior to neutrophil engraftment. For 42 evaluable patients, the median time to neutrophil and platelet engraftment was 15 (12-26) days and 22 (12-100) days, respectively. At the median follow-up time of 18.5 (0.6-74.2) months, the overall survival rates of TBI-regimen and Thio-regimen were 63.68 and 61.98%, respectively (p=0.69), while the event-free survival rates of TBI-regimen and Thio-regimen were 68.82 and 66.67%, respectively (p=0.61). Viral infections, CMV, BKV and adenovirus, were the most common infectious complications and were comparable in both groups. Moreover, rates of acute and chronic GVHD in both groups were not significantly different. Relapse was the most common cause of death in both regimens while non-relapse mortality rates of both regimens were approximately 17%. Haplo-identical SCT in high-risk pediatric hematologic malignancies using Thio-regimen had comparable clinical outcomes and complications as those using TBI-regimen.