Introduction: Obstructive jaundice in surgical hospitals is relatively common (2.6-23.7%). And it is one of the leader in the liver failure development with the severe homeostasis disorders appearanced. So, the analysis of the results of improving the surgical treatment of obstructive jaundice syndrome of benign genesis has been conducted from 2015 to 2019. Materials and Methods: The results of surgical treatment of 142 patients with cholelithiasis (gallstone disease) complicated by obstructive jaundice of benign genesis were analyzed: 95 females (66.9%) and 47 (33.1%) male patients. Patients were divided into two groups (experimental and control) according to the surgery method was used. Results: 5 complications (7.2%) and in 5 patients (7.2%) were fixed in the experimental group. However, only in a single complication was the II degree of severity according to the Clavien-Dindo classification. Control group had more complications cases: 18 (24.7%) in 13 patients (17.8%) ‑ (χ2=7.922, p=0.005). Mortality rate was also different: absent in the main group and 4 cases (5.5%) in the control one because of hepatic-renal failure against the background of severe intoxication (2 cases), massive pulmonary embolism (1 case), and disseminated intravascular coagulation syndrome (1 case).