Background and Aims: Prevention of the start of the neural cascade may result in long-term advantages by the elimination of hypersensitivity produced by noxious stimulus. This study was designed to evaluate postoperative pain and long-term functional outcomes after pre-emptive ultrasound (US)-guided caudal analgesia in patients undergoing spinal laminectomy. Methods: A total of 90 consecutive patients, aged 20 to 60 years, of either sex, scheduled for elective spinal laminectomy under general anaesthesia were randomly allocated to two groups. Group M (n = 45) received 3 mg morphine + 0.25% bupivacaine (25 ml), whereas group B (n = 45) was administered 0.25% bupivacaine (25 ml) in caudal block. The primary outcome was to observe postoperative static and dynamic pain using the Verbal Numerical Rating Score (VNRS) for 24 h. The secondary outcome was to record functional outcomes using two questionnaires—Oswestry Disability Index (ODI) and Rolland Morris Disability Questionnaire (RMDQ) during the preoperative period, at 1 month and 3 months postoperatively. Results: The static and dynamic VNRS scores were significantly less in group M ( P < 0.05). There was a statistically significant clinical improvement in RMDQ and ODI scores at all-time intervals between both groups ( P < 0.05). A four-point difference in ODI during subsequent months represents a true change and the results of our study showed an outstanding improvement of 9-11 points at 1 and 3 months from the baseline. Conclusion: The use of caudal block with the US guidance in adults undergoing spine surgeries can bring new horizons in improving pain relief and long-term functional outcomes.