Background:The visual (retinoid) cycle activity in human iPS-derived RPE (hiPS-RPE) cells has not been fully examined. Results: hiPS-RPE cells showed a functional visual cycle in both in vitro and in vivo. Conclusion: hiPS-RPE cell could provide potential treatment options for retinal degenerative diseases. Significance: hiPS-RPE cells with functional visual cycle proteins potentially could remedy certain degenerative retinal diseases.
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