Background: Psoriasis is a chronic autoimmune skin disorder characterized by thick skin patches, which are typically red, scaly and itchy. Topical drug delivery is backbone in mild and moderate psoriasis as well as useful complementary therapy to systemic therapy in severe conditions. Aim: The attempt was made to formulate, optimized and evaluate novel liposhpere based drug delivery system containing anti-psoriatic herbal drug such as Commiphora mukul and Quercetin for treatment of psoriasis. Materials and Methods: Liposphere were prepared separately for both the drugs by using Precirol ATO 5, Phosphotidylcholine, poloxamer 338. Physicochemical characteristics of the liposphere such as, particle size, drug encapsulation efficiency were determined. Also, drug release and in vitro skin permeability were evaluated using Franz diffusion cells. Results: The results showed that the maximum encapsulation efficiency was 83% and 81.77% for Commiphora mukul and Quercetin loaded liposphere respectively. In vitro study was observed that F1 liposphere gel attributed 89.28 % release in 1440 min (24 hr) and F2 conventional cream batch attributed 80.24% release in 540 min (9 hr). As per the result it was observed that liposphere gel gives more sustained release as compared to conventional cream. The results substantiate that liposphere gel containing combination of Commiphora mukul and Quercetin can be an efficacious for the treatment of psoriasis.

Background: Cosmeceuticals are drugs, cosmetics, or a combination of both.Cosmeceuticals are personal care products that not only beautify but also need to have healing, therapeutic, and disease-fighting characteristics. For decades, phytocompounds have been employed in cosmeceuticals and have shown potential in applications such as moisturizing, sunscreen, antiaging, and hair-based therapy. The inability of phytocompounds to easily penetrate through the skin and their instability limit their usage in cosmetic products. This can be overcome by incorporating nanotechnology into cosmetic products for a more stable and long-lasting release.Nanotechnology's substantial impact on the cosmetics industry is due to the improved properties attained by particles at the nano scale, such as color, solubility, and transparency. Liposomes, solid lipid nanoparticles, niosomes, and many varieties of nanoparticulate systems are commonly used in cosmetics. Safety concerns for the usage of nanomaterials in cosmeceuticals have been raised lately, hence causing the restriction on the use of nanomaterials by cosmetic companies and enforcing laws demanding thorough safety testing prior to market entry.Aim: This review focuses on the types of nanomaterials used in phytocosmetics, along with the potential hazards they pose to human life and the environment, and what legislation has been enacted or can be enacted to address them. Methods:For relevant literature, a literature search was conducted using PubMed, ScienceDirect, and Google Scholar. Nanotechnology, cosmeceuticals, herbal cosmetics, and other related topics were researched and evaluated in articles published between 2016 and 2022.Results: Herbal drugs provide a tremendous range of therapeutic benefits. And when nanoparticles were introduced to the personal care industry, the quality of the final product containing phyto-compounds continued to rise. Unfortunately, because these nano components can permeate intact skin barriers and create unwanted consequences, this revolution comes with a slew of health risks. Conclusion:The cosmeceutical industry's expansion and growth in the application of herbal compounds, as well as the entrance of nanotechnology into the cosmeceuticals business, entail the urgent need for scientific research into their efficacy, safety profile, and use.

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Regenerative medicine is the science of replacing engineering, regenerating human cells, tissues, or organs to restore or establish normal function and has now reached its potential due to its ability to deliver cell and tissue constructs to the human body thus providing therapeutic assistance of its innate healing responses. It further comprehends the cellular and molecular differences between regenerating and non-regenerating tissues thus resulting in restoring tissue structure and function in damaged, non-regenerating tissues. Replaced or repaired tissues should be indistinguishable from normal, healthy tissues in structure and function. Cellular therapy is one such strategy wherein various cell types are isolated and used that help in understanding their mechanism of action as well as their regenerative properties when they are utilized with different biomaterials as an extracellular matrix. As scaffolds provide targeted cell growth, stem cell delivery through scaffolding technology is another regenerative therapy that is used. The process of electrospinning is used for the generation of scaffolds. Problems like the unavailability of organs for transplantation prevails and thus regenerative medicine therapy has proved to be applicable in such cases.

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