Purpose. To determine whether the diagnosis of sleep apnea syndrome (SAS) represents a risk-factor for glaucoma. Design. Retrospective records review. Methods. Records in an electronic database which exists at the Birmingham, Alabama Veterans' Affairs Medical Center (BVAMC) permit data retrieval and sorting based on diagnostic and procedural codes. Deidentified data of those having had an eye examination and a diagnostic code (ICD-9) for either sleep apnea or glaucoma were included. Statistical Analyses. SPSS version 19 was used to produce crosstabs and to conduct a bivariate logistic regression that examined the relationship between SAS and glaucoma. Results. A total of 70,960 unique records were included for analysis. Of the 2,725 patients with a diagnosis of sleep apnea, 228 (8.37%) also had a diagnosis of glaucoma. Diagnosis of glaucoma was present in 3,410 patients among 68,235 patients (5.00%) without sleep apnea. Bivariate logistic regression analysis yielded an odds ratio of 1.736 (P < 0.001) suggesting that individuals with SAS are more likely to have a coexisting diagnosis of glaucoma than individuals without SAS. Conclusions. Results of this investigation suggest that SAS may represent a significant risk factor for glaucoma and this should be considered when managing patients who report that diagnosis.