Background Many preschool-age children meet criteria for psychiatric disorders, and rates approach those observed in later childhood and adolescence. However, there is a paucity of longitudinal research examining the outcomes of preschool diagnoses. Methods Families with a 3-year-old child (N=559) were recruited from the community. Primary caregivers were interviewed using the Preschool Age Psychiatric Assessment when children were 3 years old (n=541), and, along with children, using the Schedule for Affective Disorders and Schizophrenia for School-Age Children Present and Lifetime Version when children were 9 and 12 years old. Results Rates of disruptive behavior disorders (DBD) decreased from preschool to middle childhood and early adolescence, whereas rates of attention-deficit/hyperactivity disorder (ADHD) increased. Rates of any psychiatric disorder and depression increased from preschool to early adolescence only. Preschoolers with a diagnosis were over twice as likely to have a diagnosis during later periods. Homotypic continuity was present for anxiety disorders from preschool to middle childhood, for ADHD from preschool to early adolescence, and for DBD through both later time points. There was heterotypic continuity between preschool anxiety and early adolescent depression, and between preschool ADHD and early adolescent DBD. Dimensional symptom scores showed homotypic continuity for all diagnostic categories as well as a number of heterotypic associations. Conclusions Results provide moderate support for the predictive validity of psychiatric disorders in preschoolers. Psychopathology in preschool is a significant risk factor for future psychiatric disorders during middle childhood and early adolescence.

Seventy-nine 3-year olds and their mothers participated in a laboratory-based task to assess maternal hostility. Mothers also reported their behavioral regulation of their child. Seven years later, functional magnetic resonance imaging data were acquired while viewing emotional faces and completing a reward processing task. Maternal hostility predicted more negative amygdala connectivity during exposure to sad relative to neutral faces with frontal and parietal regions as well as more negative left ventral striatal connectivity during monetary gain relative to loss feedback with the right posterior orbital frontal cortex and right inferior frontal gyrus. In contrast, maternal regulation predicted enhanced cingulo-frontal connectivity during monetary gain relative to loss feedback. Results suggest parenting is associated with alterations in emotion and reward processing circuitry 7-8 years later.

Statistical interactions between two continuous variables in linear regression are common in psychological science. As a follow-up analysis of how the moderator impacts the predictor-outcome relationship, researchers often use the pick-a-point simple slopes method. The simple slopes method requires researchers to make two decisions: (a) which moderator values should be used for plotting and testing simple slopes, and (b) which predictor should be considered the moderator. These decisions are meant to be driven by theory, but in practice researchers may use arbitrary conventions or theoretical reasons may not exist. Even when done thoughtfully, simple slopes analysis omits important information about the interaction. Consequently, it is problematic that the simple slopes approach is the primary basis for interpreting interactions. A more nuanced alternative is to utilize the Johnson-Neyman technique in conjunction with a regression plane depicting the interaction effect in three-dimensional space. This approach does not involve picking points but rather shows the slopes at all possible values of the predictor variables and gives both predictors equal weight instead of selecting a de facto moderator. Because this approach is complex and user-friendly implementation tools are lacking, we present a tutorial explaining the Johnson-Neyman technique and how to visualize interactions in 3-D space along with a new open-source tool that completes these procedures. We discuss how this approach facilitates interpretation and communication as well as its implications for replication efforts, transparency, and clinical applications.

BackgroundReward processing deficits have been implicated in the etiology of depression. A blunted reward positivity (RewP), an event-related potential elicited by feedback to monetary gain relative to loss, predicts new onsets and increases in depression symptoms. Etiological models of depression also highlight stressful life events. However, no studies have examined whether stressful life events moderate the effect of the RewP on subsequent depression symptoms. We examined this question during the key developmental transition from childhood to adolescence.MethodsA community sample of 369 children (mean age of 9) completed a self-report measure of depression symptoms. The RewP to winning v. losing was elicited using a monetary reward task. Three years later, we assessed stressful life events occurring in the year prior to the follow-up. Youth depressive symptoms were rated by the children and their parents at baseline and follow-up.ResultsStressful life events moderated the effect of the RewP on depression symptoms at follow-up such that a blunted RewP predicted higher depression symptoms in individuals with higher levels of stressful life events. This effect was also evident when events that were independent of the youth's behavior were examined separately.ConclusionsThese results suggest that the RewP reflects a vulnerability for depression that is activated by stress.

In this article, we summarize findings from the Stony Brook Temperament Study, which seeks to elucidate the early antecedents and pathways to later depressive and anxiety disorders. The study focuses on parents’ internalizing disorders and children’s early temperament as distal risk factors that operate, in part, through biobehavioral reward and threat systems. We summarize findings linking parents’ emotional disorders and observations of children’s early temperament to subsequent neural measures of children’s affective processing. Next, we review findings showing that children’s temperament and affective processing predict subsequent depression and anxiety. We also show that many of these associations are moderated by environmental factors, such as parenting and stress. Finally, we relate our findings to literature on the relationships of early temperament and affective processing to anxiety and depression in youth.