The renewed popularity of urban markets has generated substantial attention among policymakers, planners and urban scholars. In addition to their potential local economic impact, markets provide spaces for a variety of social exchanges and interactions that may strengthen communal ties, reproduce existing social tensions or simply reflect everyday diversity; consequently, the social functions of urban markets differ depending on the specific social, political and economic context in which individual markets operate. Based on data from interviews, questionnaires and participant observation, this article examines social exchanges and interactions within wet markets (meat, fish, fruits and vegetable markets) in Singapore. The types of social interactions found in wet markets are wide-ranging and informal, and occur across different ethnicities, generations, social statuses and classes; they can range from casual exchanges to planned gatherings to sustained relations based on mutual reciprocity and trust. Wet markets are significant to Singaporeans because they are spaces of unmediated social interactions and, within the context of state governance and ongoing modernisation, increasingly exceptional. The attachment to wet markets is a collective, social response to an ongoing process in which existing and meaningful social spaces (e.g. neighbourhoods and markets) are being erased by a redeveloped urban landscape, a concomitant disappearance of unregulated community space, and the pervasiveness of normative consumerism.

The sense of touch allows us to infer objects' physical properties, while the same input also produces affective sensations. These affective sensations are important for interpersonal relationships and personal well-being, which raises the possibility that tactile preferences are adapted to the characteristics of the skin. Previous studies examined how physical properties such as surface roughness and temperature influence affective sensations; however, little is known about the effect of compliance (physical correlate of softness) on pleasantness. Thus, we investigated the psychophysical link between softness and pleasantness. Pieces of human skin-like rubber with different compliances were pressed against participants' fingers. Two groups of participants numerically estimated the perceived magnitude of either pleasantness or softness. The perceived magnitude of pleasantness and softness both increased monotonically as a function of increasing object compliance, levelling off at around the end of the stimulus range. However, inter-subject variability was greater for pleasantness than for perceived softness, whereas the slope of the linear function fit to the magnitude estimates was steeper for softness than for pleasantness. These results indicate that object compliance is a critical physical determinant for pleasantness, whereas the effect of compliance on pleasantness was more variable among individuals than the effect on softness was.

Touching an object can elicit affective sensations. Because these sensations are critical for social interaction, tactile preferences may be adapted to the characteristics of the human body. We have previously shown that compliance, a physical correlate of softness, increased the tactile pleasantness of a deformable surface. However, the extent to which object compliance similar to the human body elicits tactile pleasantness remains unknown. We addressed this question by using a wide range of compliances and by measuring the distribution of compliance of human body parts. The participants numerically estimated the perceived pleasantness or softness while pushing tactile stimuli with their right index fingers. The perceived softness monotonically increased with increasing compliance and then leveled off around the end of the stimulus range. By contrast, pleasantness showed an inverse U pattern as a function of compliance, reaching the maximum between 5 and 7 mm/N. This range of compliance was within that for both hand and arm. These results indicate that objects with similar compliance levels as those of human body parts yield the highest pleasantness when pushing them.

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Boosted protease inhibitors (PI/b) have played an instrumental role in decreasing mortality among people living with HIV (PLWH). 1 However, this class of antiretrovirals has been associated with disadvantages such as drug-drug interactions (DDIs). 1 The cytochrome P450 3A4 (CY-P3A4) inhibitors ritonavir and cobicistat are used to boost PI concentrations to improve efficacy, administration frequency, and genetic barrier to resistance. However, potentially dangerous DDIs may occur during coadministration of comedications with PI/b, especially in ageing populations affected by polymorbidity and polypharmacy. 2 This is especially true for certain drugs, such as anticholinergic drugs or drugs with narrow therapeutic indexes. 3 Second-generation integrase strand inhibitors (INSTIs), namely dolutegravir (DTG) and bictegravir (BIC) are also characterized by a high genetic barrier to resistance 4 and have been used as replacement agents for PI/b in clinical trials including subjects with nucleoside reverse transcriptase inhibitors (NRTI) resistance. [5][6][7][8] Importantly, they are not enzyme inducers or inhibitors, and their DDI potential is substantially lower than PI/b. 4 The switch from PI/b to INSTIbased regimens can potentially reduce DDIs and the risks associated to polypharmacy.