The Toxic Epidermal Necrolysis-specific severity of illness score (SCORTEN) was developed to predict mortality in patients with Stevens Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). Several studies have attempted to assess the accuracy of SCORTEN with mixed results. The objective of this study is to compare the predicted and actual mortality for patients with SJS/TEN admitted to a single high-volume burn center.This retrospective study included adult and pediatric patients admitted to our burn center with biopsy-confirmed SJS/TEN between February 2008 and February 2016. SCORTEN scores were calculated for each patient on days 1 and 3 of admission. The primary endpoint was predicted vs actual in-hospital mortality. Secondary endpoints included the association of SCORTEN, as well as individual components of SCORTEN, with hospital length of stay, length of stay in the intensive care unit, and in-hospital complications.Of 128 patients included, the mean age was 44.5 years, 40.6% (n = 52) were males, and 50.0% (n = 64) were Caucasians. The median TBSA was 12.25% on day 1 and 25% on day 3. The median SCORTEN at admission was 2 (interquartile range: 1-3.5). There were a total of 20 deaths (17.2%). SCORTEN exhibited good discrimination (c-statistic = 0.83, 95% CI: 0.75-0.91) and performed directionally as expected, but a low but nonsignificant standardized mortality ratio (75.3%, P = .164) and a Hosmer-Lemeshow test of borderline significance (P = .088) make the model's fit unclear.The accuracy of the SCORTEN model in predicting mortality for SJS/TEN patients treated in a burn center remains unclear. This study may encourage future multicenter studies to further clarify its predictive ability and may also enhance future investigation into the use of a reformulated or reweighted SCORTEN.

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Recent evidence suggests differential involvement of opioid receptor subtypes in the anxiolytic efficacy of diverse compounds including conventional benzodiazepines. The insensitivity of 129 mice to the anxiolytic action of chlordiazepoxide, coupled with their atypical anxiolytic response to naloxone (but not more selective opioid receptor antagonists), suggests an abnormality in anxiety-related neurocircuitry involving opioid-GABA interactions.

Research and education can be distinctly separate activities in institutions, where academics try to divide their time between the two roles. Many research initiatives necessitate large-scale funding to be completed. In response, this paper presents an alternate strategy in which educational design initiatives can promote academic research activities. The study looks at how a design-led entrepreneurial approach combines research and education to create marketable solutions. A literature review was undertaken to understand the disconnect between academic pedagogy, postgraduate, design-driven research and design entrepreneurship. An undergraduate Product Design degree course was also examined to understand the means through which innovative solutions are incubated. We then applied our findings to progress a final year project through master's level with a commercial focus to determine the viability of our approach. This study presents findings and lessons learned from a paradigm built inside a research cluster, in which viable design proposals are incubated as undergraduate final year projects (FYP) and then selected for postgraduate development with the goal of commercialization. A variety of difficulties and possibilities, as well as lessons learned, were recognized, including choosing the right topic to develop, forming partnerships with different disciplines, intellectual property, money, expertise, and resources. By bringing together the often-separate entities of research and education, this paper shows how research and educational activities are not mutually exclusive but can be combined to provide rich educational experiences along with meaningful research outputs.

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