Because ≈90% of malaria cases occur in Africa, emergence of artemisinin-resistant Plasmodium falciparum in Africa poses a serious public health threat. To assess emergence of artemisinin-resistant parasites in Uganda during 2014–2016, we used the recently developed ex vivo ring-stage survival assay, which estimates ring-stage–specific P. falciparum susceptibility to artemisinin. We conducted 4 cross-sectional surveys to assess artemisinin sensitivity in Gulu, Uganda. Among 194 isolates, survival rates (ratio of viable drug-exposed parasites to drug-nonexposed controls) were high (>10%) for 4 isolates. Similar rates have been closely associated with delayed parasite clearance after drug treatment and are considered to be a proxy for the artemisinin-resistant phenotype. Of these, the PfKelch13 mutation was observed in only 1 isolate, A675V. Population genetics analysis suggested that these possibly artemisinin-resistant isolates originated in Africa. Large-scale surveillance of possibly artemisinin-resistant parasites in Africa would provide useful information about treatment outcomes and help regional malaria control.
LoRa is one of the promising techniques for enabling Low Power Wide Area Networks (LPWANs) for future Internet-of-Things (IoT) devices. Although LoRa allows flexible adaptations of coverage and data rates, it is subject to intrinsic types of interferences: co-SF interferences where end-devices with the same Spreading Factors (SFs) are subject to collisions, and inter-SF interferences where end-devices with different SFs experience collisions. Most current works have considered perfect orthogonality among different SFs. In this work, we provide a theoretical analysis of the achievable LoRa throughput in uplink, where the capture conditions specific to LoRa are included. Results show the accuracy of our analysis despite approximations, and the throughput losses from imperfect SF orthogonality, under different SF allocations. Our analysis will enable the design of specific SF allocation mechanisms, in view of further throughput enhancements. 1
We address the problem of radio resource allocation in the Downlink (DL) of relay-aided cellular system, based on OFDMA transmission technology. There has been little work on specific resource allocation algorithms for this system in the literature, although these are the key elements for realizing the potential capacity and coverage increase offered by the relay. Therefore, we propose two resource allocation algorithms which improve the overall throughput and coverage compared to a system without relay. The advantage of our algorithms is that they perform well while minimizing the complexity and the required amount of Channel State Information (CSI), making them suitable for practical use.
Long-range low-power wireless communications, such as LoRa, are used in many IoT and environmental monitoring applications. They typically increase the communication range to several kilometers, at the cost of reducing the bitrate to a few bits per seconds. Collisions further reduce the performance of these communications. In this paper, we propose two algorithms to decode colliding signals: one algorithm requires the transmitters to be slightly desynchronized, and the other requires the transmitters to be synchronized. To do so, we use the timing information to match the correct symbols to the correct transmitters. We show that our algorithms are able to significantly improve the overall throughput of LoRa.
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