Background: Diabetes is a chronic disease, affecting more than 8.5 % adults population in the world. Among various issues caused by diabetes, wound healing is a major cause of concern. Objective: Injuries are most common, can be caused normally like abrasion, laceration (cuts), injury, etc. But in diabetes, they do not heal so easily and cause problems. It can be due to compromised immune system, neuropathy, poor circulation, infections etc., which could lead to amputation or even death. Current therapies, for the treatment of wound healing in diabetic patients, have side effects of their own as there is no particular drug for the healing of wounds Methods: Numerous survey in Literature was carried out to reveal the obstacles in diabetic wound healing and current approaches to its management with emphasis on alternative therapies. Relevant peer-reviewed research publications were searched through various online bibliographic databases such as ScienceDirect, PubMed, Scopus, Google Scholar, and ResearchGate (all English-language articles). Results: Repurposed drugs include a class of statin, phenytoin, estrogen, DPP4 inhibitors. Plants with wound healing activity include Rosmarinus officinalis, Radix Rehmannia, Carica papaya, Aloe vera, Catharanthus roseus, Punica granatum, etc. have been explored in Pre-clinical studies. Besides these studies, a lot of other studies including clinical trials have been performed for wound healing in diabetes by using different procedures like Honey-dressing, Royal Jelly, Extracorporeal Shock wave therapy, Manuka honey-impregnated dressing, LeucoPatch system, etc. Conclusion: In this review, an approach was made to study wound healing in diabetes and various options that could be best suited for the treatment of wounds in Diabetes.

Background Parkinson’s disease (PD) is associated with motor and behavioral dysfunctions. Mitochondrial damage, increased oxidative stress, and the formation of Lewy bodies by misfolded proteins are major pathways for the development of PD. Using antioxidants could delay neurodegeneration in parkinsonism and improve the symptoms. We investigated the neuroprotective effects of quercetin, curcumin, and their combination on the rotenone-induced parkinsonism model. Methods PDwas induced by administration of rotenone 2mg/kg/day for 14 days in rats. Curcumin (100, 150, and 200 mg/kg), quercetin (30, 40, and 50 mg/kg),or their combination were given orally for 14 days concurrently with rotenone and for additional 14 days. On the 28th and 29th days, behavioral and histological studies were carried out. Results In the rotenone-induced parkinsonism model, curcumin and quercetin dose-dependently improved locomotor activity, motor coordination, and mobility. Also, they increased dopamine levels and mitigated the neural damage induced by rotenone. Conclusion Both curcumin and quercetin have neuroprotective effects against parkinsonism. The combination of curcumin and quercetin has more favorable effects than usingeither drug alone.