Background: Acromegalic cardiomyopathy is a significant cardiovascular complication associated with acromegaly, a rare condition caused by excessive growth hormone production from a pituitary adenoma. While acromegaly often presents with distinct physical changes, early diagnosis can be challenging due to its insidious nature, leading to delayed recognition and the presence of multiple comorbidities at the time of diagnosis. Cardiovascular disease is the most common comorbidity in acromegaly, contributing to significant morbidity and mortality. Case presentation: This case report describes a non-hypertensive patient who presented with biventricular hypertrophy, revealing the presence of acromegalic cardiomyopathy at the age of 54. The diagnosis relied on information from clinical examination, imaging tests, and biological data. The patient successfully underwent transsphenoidal surgery to remove the pituitary adenoma, resulting in a positive outcome. Conclusions: Acromegaly patients have higher mortality rates compared to healthy individuals due to the wide array of associated comorbidities, consequently leading to a reduced life expectancy. Hence, early diagnosis and management, particularly before the age of 40, play a crucial role in mitigating the cardiovascular risks associated with acromegaly.

Background Coronary artery perforation is a rare but serious complication of percutaneous coronary interventions, that may eventually lead to major and fatal events such as myocardial infarction, cardiac tamponade, and ultimately death. The risk of coronary artery perforation is more significant during complex procedures as chronic total occlusions but it can occur in other circumstances such as oversized stents and/or balloons, excessive post-dilatation, and the use of hydrophilic wires. Coronary artery perforation is often not recognized during the procedure and the diagnosis is frequently not made until later when the patient develops signs related to pericardial effusion. Thus, causing a delay in management and worsening the prognosis. Case presentation We report a case of a distal coronary artery perforation secondary to using a hydrophilic guide in a young male patient of 52-year-old arab, initially presented with an ST-segment elevation myocardial infarction, complicated by pericardial effusion that was treated medically with a favorable outcome. Conclusions This work highlights that coronary artery perforation is a complication that must be anticipated in high-risk situations and its diagnosis must be made early to allow adequate management.

L Oxcarbazepine (OXC) est un nouveau antiepileptique de deuxième generation. Les effets secondaires et les proprietes de ce medicament sont uniques et largement inconnus. Le risque des effets indesirables augmente lorsque son taux serique depasse 20 mg/ml, le bloc auriculoventriculaire (BAV) induit par lOxcarbazepine est rare mais peut être grave, doù la necessite d être prudent et de faire plus attention avant la prescription de cette molecule avec un suivi rigoureux des patients traites par lOxcarbazepine. Dans ce rapport, nous discutons un cas rare dune femme de 52 ans, connue epileptique sous Oxcarbazepine depuis 2 ans et qui a presentee un bloc auriculo-ventriculaire variable 4 jours après laugmentation de la dose de cette molecule.