Increased asymmetric dimethylarginine (ADMA) levels and decreased homocysteine thiolactonase/paraoxonase (HTLase/PONase) activities are related to the risk of cardiovascular disease in prediabetic/diabetic patients [Prediyabetik/diyabetik hastalarda artmış asimetrik dimetilarjinin (ADMA) ve azalmış homosistein tiyolaktonaz/paraoksonaz (HTLase/PONase) aktiviteleri kardiyovasküler hastalık riski ile ilişkilidir] ABSTRACTObjective: Individuals with impaired glucose tolerance and/or impaired fasting glucose are at high risk, not only to develop diabetes mellitus, but also to experience cardiovascular disease later in their life. The aim of this study was to evaluate the cardiovascular risk markers (such as serum ADMA, homocysteine, high-sensitivity C-reactive protein, small dense LDL levels, paraoxonase/homocysteine thiolactonase and platelet-activating factor acetylhydrolase activities between patients with diabetes, prediabetes, and control group. Methods: Subjects were grouped as Type 2 diabetes mellitus (n=20), IGT (n=16), IFG (n=19) and control group (n=23). Enzyme activities were measured spectrophotometrically. ADMA levels were measured by HPLC. Serum concentrations of homocysteine were measured by fluorescence polarization immunoassay. sLDL was measured by using heparin-magnesium precipitation method. h-CRP was measured by using immuno nephelometric method. Results: Plasma ADMA levels were significantly lower in the control group than the IFG, IGT, DM groups (p<0.05, p<0.01, p<0.01 respectively). Serum HTLase activity was significantly higher in the control group than in the IFG, IGT, DM groups (p<0.01, p<0.01, p<0.001 respectively). No difference was found in plasma Hcy, sLDL, h-CRP concentrations and PAF-AH acivity between groups. Conclusion: We concluded that increased ADMA levels and decreased HTLase/PONase activities in prediabetic patients can indicate that the risk of atherosclerosis in prediabetic stage.

Tyrosine kinase inhibitors are molecules that block various intracellular signaling pathways. Trials with some tyrosine kinase inhibitors showed promising results in thyroid cancer. They are thought to owe their antitumor property mainly to their effect on vascular endothelial growth factor receptor which is important in angiogenesis. Axl is a receptor tyrosine kinase shown to be involved in proliferation migration and survival of cells. Recent studies implied axl in thyroid cancer development. In this review, we aimed to discuss the mechanism of action of tyrosine kinase inhibitors in general and specifically focus on the axl/gas6 signaling pathway. Tirozin kinaz inhibitörleri çeflitli intraselüler sinyal yolaklar›n› bloke eden molekülleridir. Baz› tirozin kinaz inhibitörleriyle yap›lan çal›flma-lar, tiroid kanserinde ümit verici olduklar›n› göstermifltir. Antitümör özelliklerini bafll›ca, anjiogenezde önemli olan vasküler endotelyal büyüme fakötrü reseptörü üzerindeki etkilerine borçlu olduklar› düflünülmektedir. Axl, hücrelerin ço¤almas›, göçü ve sa¤kal›m›nda rolü oldu¤u gösterilmifl bir reseptör tirozin kinazd›r. Yak›n zamanda yap›lan çal›flmalar tiroid kanseri gelifliminde axl'yi iflaret etmektedir. Bu derlemede, genel olarak tirozin kinaz inhibitörlerinin etkisini tart›flmak ve özellikle axl/gas6 sinyal yola¤› üzerinde durmak istedik.Anahtar Kelimeler: Tirozin kinaz inhibitörü, axl/gas6 sinyali, Tiroid kanseri ULUSLARARASı HEMATOLOJI-ONKOLOJI DERGISI