No abstract

IntroductionAllergic contact dermatitis (ACD) is a form of dermatitis due to type 4 hypersensitivity reaction that occurs when the skin comes into contacts with the topical product. Topical nitrofurazone is a widely used antimicrobial drug in our country which is well known to cause ACD.AimIn this study, ACD cases with different clinical features attributed to the use of nitrofurazone were evaluated.Material and methodsPatients hospitalized in our clinic between 2013 and 2017 with ACD diagnosis due to nitrofurazone were evaluated. The patient age, gender, atopy histories, clinical features, dissemination of the lesions, treatment given were reviewed.ResultsIn a 5-year period, 58 cases were identified and their data were analysed. Twelve patients were female (21%), 46 patients were male (79%). Clinical presentations were dyshidrosiform (45%), excoriated papules and plaques (33%), combined (21%), and erythroderma in one patient. The dissemination was generalized in 34 patients, localized in 14 patients, and local spread in 10 patients. The mean hospitalization time was 7 ±3 days, and ranged from 3 to 18 days.ConclusionsThere may be widespread and severe ACD due to the use of nitrofurazone. Topical nitrofurazone should not be applied on damaged skin as sensitization may develop. Patients and physicians should be aware of the ACD risk associated with topical nitrofurazone, which is also commonly used as self-medication, physicians should take a detailed history of the drug use and products containing nitrofurazone should not be used in conditions where skin integrity is not intact, whenever possible.

Celiac disease (CD) can affect almost all organs of the body, including the nervous system, liver, skin, reproductive and musculoskeletal systems. In this study, it is aimed to determine the prevalence of extra-intestinal manifestations (EIMs) in adult celiac patients and to investigate the factors affecting the development of EIMs. The study included 230 celiac patients who were diagnosed and followed-up in our clinics between 2015-2019. The demographic and anthropometric characteristics, initial admissi on complaints, disease duration and dietary compliance of the patients were documented. All EIMs that accompanied the celiac disease were recorded, and their relationship with risk factors was analyzed. The age range of the patients was 18-72 years, and the mean age was 33.4±10.6 years. One hundred seventy two (74.8%) patients were female and disease follow-up was 4.8±3.5 years. The number of patients with accompanying EIMs was 202 (87.8%). Osteoporosis/osteopenia was found in 146(63.5%) patients, oral involvement in 116(50.4%) patients, arthritis/arthralgia in 96(41.7%) patients as the most common comorbidities. It was determined that, there was a significant relationship between EIM and body mass index. Although the EIMs development was less in patients wh o had strict diet; however, this was not statistically significant. The majority of adult celiac patients were found to be accompanied by EIMs. The diagnosis is delayed due to various clinical presentations. Lack of delay in diagnosis of celiac disease and consequently reduced gluten exposure seem to be the only factor in preventing some EIMs

BACKGROUND: While a life-threatening course is observed in 2–3% of patients with acute pancreatitis (AP), mortality can be up to 50% in severe AP. In our study, we research relationship between calcium level and Modified Balthazar (MB) score. METHODS: 354 patients who were followed up with a diagnosis of AP between 2013 and 2019 were included in our study. Serum calcium level was measured within the first 24 h. Abdominal computed tomography (CT) was performed in all patients in the first 12 h and between 3 and 7 days. The severity of AP was determined according to the MB classification. The correlation between calcium level and MB classification was examined. RESULTS: 206 (58.2%) of the patients were women. Mean age was 54.8±17.9 years (range: 18–100). It was observed that the rate of severe AP was significantly higher in the low calcium group compared to the MB classification in which tomographies taken at admission and 72 h after were evaluated (p<0.05). Furthermore, progression was higher in low calcium group (p<0.05). The cutoff value was 9.35 mg/dl for the ROC analysis performed to distinguish mild pancreatitis from moderate-severe pancreatitis according to the MB classification performed by CT obtained after 72 h based on the Ca values. For the cutoff value of 9.35 mg/dl (AUC: 0.581, p=0.018, 95% Cl: 0.514–0.649), the sensitivity was 57.4% and the specificity was 53.1%. CONCLUSION: Since there is a correlation between the initial calcium level and the severity of the disease according to the CT-scan obtained later, the calcium level gives us an idea of the course of the disease.

During pregnancy, skin lesions can occur as a result of immunological, endocrine, metabolic and vascular changes (1). Due to the presence of hormone receptors in the skin and its related structures, several changes can be observed in eccrine and apocrine units, the pilosebaceous unit and the vascular system. Those changes can be related to protein and steroid structures released by the fetoplacental unit as well as increased endocrine gland activities on the part of the hypophysis, thyroid and adrenal glands (2). Pregnancy-related skin changes include pregnancyinduced physiological skin changes, specific dermatosis of pregnancy and nonspecific dermatosis (3). Herein, we investigated an incidence and features of specific dermatosis of pregnancy, and nonspecific dermatosis in pregnant women who were admitted to the emergency department for skin related complaints. Materials and Methods We enrolled 99 pregnant patients who were admitted to the emergency department between January 2010 and November 2011. We retrospectively collected clinical and laboratory findings, diagnoses, administered treatments, and admission rates from the medical charts. The study protocol was carried out in accordance with the Helsinki Declaration as revised in 2013. The study protocol was approved by the Van Yuzuncu Yil University, Faculty of Medicine of local ethics committee (approval number: 5/ 2014). Clinical and laboratory findings including complete blood count, comprehensive metabolic panel, Creactive protein test, urinalysis, skin biopsy, and