Thrombosis and bleeding are the main complications of chronic myeloproliferative diseases. Mean platelet volume (MPV) is an important indicator of the platelet activation. The aim of the present study was to assess the interrelationships between MPV, JAK-2 gene mutation and thromboembolic events in patients with ET and PV. Patients with ET (n = 60) and PV (n = 46) were compared to the secondary erythrocytosis group (n = 19); and a control group of age and sex matched healthy volunteers (n = 52). Besides demographic, clinical and laboratory data; thrombotic and hemorrhagic events were recorded for each patient. Platelet counts, MPV and JAK2 mutations were studied; and their relation with thromboembolic events were investigated using SPSS program for statistical analysis. There was no significant difference between groups regarding age ( = 0.188). Mean platelet count was significantly higher in ET group than other groups ( < 0.0001). Mean platelet count in PV group was significantly higher than control ( < 0.0001) and secondary erythrocytosis groups ( < 0.0001). In the ET group, MPV values were significantly lower than the control group and PV group. In the ET group, those with thromboembolia had lower platelet counts. There was no relation between MPV and thromboembolic event rate in PV, ET and secondary erithrocytosis groups; while no event was recorded in the control group. There was no relation between thromboembolic event rate and JAK 2 mutation. The association of JAK-2 mutation and high MPV especially in ET and PV groups does not contribute to the thromboembolic events.

The aim of this study was to assess the possible influence of genetic polymorphisms in hOGG1, XRCC1, XRCC3, XPD, XPG and APE1 on the observed DNA damage in a group of Turkish myelodysplastic syndrome (MDS) patients. A total of 39 patients with myelodysplastic syndrome and 78 age-matched healthy control subjects were included in our study. Polymerase chain reaction/restriction fragment length polymorphism analysis was performed for the detection of DNA repair gene variants. No significant differences in DNA repair enzymes APE1, XRCC1 and XPG were found between MDS patients and controls. On the other hand, XRCC3, XPD and hOGG1 were associated with an increased risk of MDS (p=0.004, p=0.000, p=0.017, respectively). Specifically, Thr/Met genotype was more relevant in patients (p=0.026) in XRCC3; in hOGG1, Cys+ genotype was found higher in patients (p=0.017); and in XPD, Gln/Gln genotypes were found higher in the patient (p=0.001). In conclusion, XRCC3, XPD and hOGG1 genotypes are associated with an increased MDS risk, suggesting their possible involvement in the pathogenesis and biology of this disease.

OzetPedinküler halüsinoz, beyin sapi ve talamus gibi yapilarin etkilenmesiyle ortaya çikan kisa süreli renkli, canh görsei halusinasyonlarla karakterize bir sendromdur.Etiyolojide daha cok vasküler hadiseler ve enfeksiyonlar yer almaktadir. Literatürde mulripl skleroza bagli pedinküler hallusinozis olgusu oldukça az sayidadir. Biz bu yazida multipl skleroz tanisi olan, 46 yaçindaki bir hastada geli §en pedinküler halusinozisi sunduk. (Turk NöroJoji Dergisi 2013; 19:143-144) Anahtar Kelimeler: Pedinküler halusinozis, multipl skleroz, beyin sapi Summary Peduncular hallucinosis is a snydrome characterized by vivid, colored visual hallucinations due to brain stem and rhalamic involvement. The etiology of peduncular hallucinosis mostly involves lesions of vascular nature and infections. The cases of peduncular hallusinosis due to multiple sclerosis is very rare in the literature.In this report we presented a peduncular hallucinosis case who is a 46 year old woman with multiple sclerosis diagnosis.

Öz Amaç: Akut Miyokard İnfarktüsü (AMİ) geçirmiş hastalarda miyokard performans indeksi (MPİ) önemli bir prognostik parametredir. Bu çalışmada, kardiyovasküler hastalıklarda prognozu etkileyen bir risk faktörü olan MPİ ve ejeksiyon fraksiyonu (EF) arasındaki ilişkiyi inceledik. Gereç ve Yöntem: 2010 Ekim ve Kasım tarihleri arasında hastanemizde yatan non-ST elevasyonlu AMİ olan 35 hastayı inceledik. MPİ'nin sayısal değerini elde etmede pulsed Doppler ekokardiyografi kullanıldı. Bulgular: Ortalama MPI düzeyi 0.45±0.15 olarak bulundu. MPİ ile yaş (p=0,430), boy (p=0,993) ve EF (p=0,451) arasında anlamlı bir ilişki saptanmadı. Diabetes mellitusu olan ve olmayan hastalara ilişkin, yaş (p=0,959), MPİ (p=0,986), boy (p=0,888) ve EF (p=0,355) değerleri arasında anlamlı bir ilişki saptanmadı. Hipertansiyon (HT) ve yaş (p=0,01) arasında yüksek anlamlı bir ilişki saptandı. Ancak HT ve boy (p=0,154), MPİ (p=0,205) ve EF (p=0,837) arasında anlamlı bir ilişki saptanmadı. Sonuç: Çalışmamızda, non-ST elevasyolu AMİ'li hastalarda MPİ ile hipertansiyon, diabetes mellitus, yaş, EF ve boy arasında anlamlı bir ilişki saptanmadı. Hasta sayısının az olması ve hastaların akut dönemde gözlem altında olmalarına rağmen, kronik dönem için izlem eksikliğinin olması bunun nedeni olabilir.

Aim: Aim of this study is to investigate the relationship between myocardium performance index (MPI) which is considered as cardiovascular prognosis effecting factor and CRP, MPV. Material and Method