Figure 1. ECG image obtained after the first drug reaction. A 1-mm ST-segment depression in DI, DII, aVL, and aVF and T-wave negativity in V1-V4 were observed

CT-1 was found to be associated with Tn-I, which is used to detect myocardial damage after OPCAB surgery. CT-1 may also be used to detect myocardial damage.

Objective:Our aim was to assess the value of coronary artery calcium score (CACS) in the early diagnosis of coronary artery disease in Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage II chronic obstructive pulmonary disease (COPD) patients and to identify high-risk patients.Methods:Forty-two patients with GOLD stage II COPD and 31 healthy control subjects were enrolled in the study. This study was designed as a prospective observational cross-sectional study. Pearson’s correlation coefficient was used for comparisons between groups. Criteria for stage II COPD diagnosis were forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) of <70% and 50%≤FEV1<80%. Excluded from the study were individuals who had a previous diagnosis of coronary artery disease, GOLD stage I-III-IV COPD, or left ventricular systolic dysfunction.Results:As compared with the control group, CACS values were significantly higher in the patient group (p=0.030 and 0.001, respectively). CACS was significantly higher in male patients with a positive family history, physical inactivity, long duration of disease, and low FEV1 (0.027, 0.008; 0.001 and 0.001; 0.001, respectively). Logistical regression analysis of sex, age, diabetes mellitus, hypertension, cigarette smoking, family history, physical inactivity, and FEV1 values showed that physical inactivity was independently correlated with high CACS [odds ratio (OR): 7; confidence interval (CI): 3–20; p=0.001].Conclusion:The value of CACS is high in stage II COPD patients. Male stage II COPD patients with a disease duration of 10 years, physical inactivity, and/or a positive family history should be monitored for early stage coronary artery disease and coronary events, regardless of risk factors such as diabetes, hypertension, and hyperlipidemia.

Ö ÖZ ZE ET T AAm ma aç ç: : Varfarin, günümüzde yaygın olarak kullanılan ve dar bir terapötik pencereye sahip pıhtı önler bir ilaçtır. Besin, ilaç etkileşimi ve bireysel farklılıklar gibi faktörler varfarinin tedavi başarısını etkilemektedir. Çalışmamızın amacı, mekanik protez kapak, atriyal fibrilasyon (AF), intrakardiyak trombüs veya pulmoner emboli nedeniyle varfarin tedavisi almakta olan hastalarda, etkin International Normalized Ratio (INR) düzeyi oranlarını ve bunun etiyoloji ile olan ilişkisini değerlendirmektir. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Ocak 2012-Haziran 2012 tarihleri arasında Uludağ Üniversitesi Tıp Fakültesi Kardiyoloji Anabilim Dalı polikliniğine başvuran hastaların arşiv kayıtlarından geriye dönük olarak 6450 dosya tarandı. Mekanik protez kapak, AF, intrakardiyak trombüs veya pulmoner emboli nedeniyle warfarin tedavisi almakta olan 971 hasta çalışmaya alındı. Hastalar yaş, cinsiyet, hangi endikasyon ile varfarin verildiği ve INR düzeyleri açısından değerlendirildi. B Bu ul lg gu ul la ar r: : Çalışmamızda hastaların %47,6'sı etkin INR düzeyine sahipti. Etkin INR düzeyi oranı en düşük gruplar %39,6 ile mitral kapak replasmanı (MKR) yapılmış hastalar ve %33,3 ile pulmoner embolili hastalardı. Aort kapağı replasmanı (AKR) yapılmış hastalar ise %61,9 ile etkin INR oranı en yüksek grup olarak belirlendi. S So on nu uç ç: : Çalış-maya alınan hastalarda etkin INR düzeyi oranı hayli düşük saptanmıştır. Özellikle MKR yaplmış hastalarda etkin INR düzeyi oranı, diğer gruplara göre belirgin olarak daha düşüktür. Varfarin kullanan ve özellikle daha yüksek INR değeri hedeflenen protez kapağı olan hastalarda tedaviye uyum sorgulanmalıdır; ayrıca bu hastalarda, hastaların kullandığı diğer ilaçlar ve beslenme alışkanlığı da göz önüne alınarak daha sık INR takibi gerekmektedir. A An na ah ht ta ar r K Ke el li im me el le er r: : Antikoagülanlar; varfarin; uluslararası normalleştirilmiş oran A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Warfarin with a narrow therapeutic window has a wide range of use. Food and drug interactions of warfarin and the individual differences may affect the success of the warfarin treatment. The aim of this study was to investigate the rate of effective INR levels in patients receiving warfarin therapy due to the mechanical prosthetic valve, atrial fibrillation (AF), intracardiac thrombus or pulmonary embolism and the relationship between the etiology and the efficacy of warfarin. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Archive records of 6450 patients presenting to the outpatient clinic of the Department of Cardiology, Uludağ University, Faculty of Medicine between January 2012-June 2012 were reviewed retrospectively. Nine hundred and seventy-one patients receiving warfarin treatment due to mechanical prosthetic valve, atrial fibrillation (AF), intracardiac thrombus or pulmonary embolism were included in the study. Medical records were reviewed for age, gender, international normalized ratio (INR) levels and indications for the w...

Close Pad usage demonstrated increased risk of vascular complications when compared with the sand bag in patients undergoing cardiac catheterizations. After the PCI, patients should be selected carefully for application of the Close Pad.