In late 2019 on 11th March 2020 a novel coronavirus, SARS-CoV-2 causing Coronavirus disease 2019 appeared in Wuhan, China and World Health Organisation declared it to have developed pandemic status. Although there are many detection techniques for the disease to control the pandemic such as RT-PCR, serological methods, or fast antigen tests, the actual problem is the prevention of the disease. The nasal cavity and rhino pharynx are key sites of the initial replication of SARS-CoV-2. In this article, the effectiveness of destrovir spray was investigated by creating a mechanical barrier in the nasal and oral mucosa, which are the entry points of the virus into the body, and to destroy the virus that comes into contact with this barrier. In the presented study, quantitation cycle (Cq) and irradiation values (RFU) of 12 different high-positive patients (Cq≤25) after application of both RT-PCR and destrovir spray were determined at different concentrations (10%, 20%, 30%, 40%, and 50%) aimed to evaluate its effectiveness. According to the results obtained by comparing the effectiveness of disinfectant with 70% ethyl alcohol on the 46 patient samples with Cq<20, 46 patient samples with Cq values between 20-25, and 46 patient samples with Cq≥25 including different variants are examined. A total of 138 COVID-19 patient samples were treated with 5% and 10% ratios of destrovir spray. Its effectiveness on Cq values and RFU was evaluated and it was aimed to compare the effectiveness of this evaluation with 96% ethyl alcohol used in the same samples.

OBJECTIVE: We aimed to develop a simple, rapid urine test based on the level of foaming that occurs in the urine sample due to the excretion of peptide structures containing amino acids specific to the antigenic structure of COVID-19. In this study, we present the preliminary results of the first clinical study with a newly developed urine foaming test (UFT). METHODS: This study was conducted in a tertiary hospital in Istanbul. After obtaining the approval of the ethics committee, urine samples were taken from three groups of patients whose informed consent was obtained. The groups were created according to the COVID-19 Diagnostic Guide of Ministry of Health: A: outpatients with suspected COVID-19, B: inpatients for follow-up and treatment, C: patients treated in intensive care unit (ICU). Also, 30 healthy volunteers were included as the control group D. Urine samples taken from all groups were delivered to the laboratory. 2.5 ml urine sample was added to the test tube and shaken for 15 seconds and the level of foam formed was visually evaluated according to the color scale. Other data of the patients were obtained from the hospital information management system and the physician caring for the patient. The clinical status, PCR test results, computed tomography (CT), if any, laboratory tests, and UFT results were compared and the level of statistical significance was expressed as p≤0.05 in the 95% confidence intervals (CI). Performance characteristics, such as sensitivity, specificity, positive and negative predictive value of the UFT, were statistically calculated according to the RT-PCR result and/or CT. RESULTS: A statistically significant difference was observed between UFT distributions of the control, outpatient, inpatient and ICU patients (p=0.0001). The results of UFT orange and red in inpatients and ICU patients were statistically significantly higher than in the control and outpatient groups. The diagnostic accuracy of UFT was detected in all group, the pooled sensitivity was 92% (95% CI: 87–95%) and specificity was 89% (95% CI: 80–98%). CONCLUSION: Our preliminary results suggest that the UFT is useful, particularly in predicting the clinical severity of COVID-19. The UFT could be recommended as a point of care test, rapid and non-invasive method in the diagnosis and follow-up of COVID-19.

Background and Aims:The real target planned is the prevention of COVID-19 using natural treatment tools, other than medical drugs, together with the use of vaccines. Similar to various viruses that lead to upper respiratory diseases, SARS-CoV-2 most frequently enters the body through the nasal cavity and oral cavity. It has been stated that the Oscardia Ledovir Spray can form a mechanical barrier in the mucosa of the nasal and oral cavities, which are the points of entry of the SARS-CoV-2 virus in the body, preventing the bonding of the virus to the receptors, and inhibiting any virus it encounters through direct contact.Methods: The present study serves as evidence for this treatment. The application of disinfectants in percentage formulations has been officially accepted by the World Health Organization to kill viruses, and this was used to compare its effectiveness with the Oscardia Ledovir Spray. The obtained new sample mixture was placed in a plate. In the course of the study, it was determined that the Oscardia Ledovir Spray has an effect mechanism similar to ethyl alcohol and disinfectants.Results: Since the Oscardia Ledovir Spray was found to have an effect mechanism similar to ethyl alcohol and disinfectants, this was considered as the preferred treatment approach. The results of the present clinical study revealed that this treatment approach is effective, particularly for SARS-CoV-2. Conclusions:The Oscardia Ledovir Spray can be considered to provide both prophylactic and therapeutic benefits, thereby contributing to humanity in improving processes that range from simple infections to serious diseases. Furthermore, it was considered that this treatment can be used for both SARS-CoV-2, and viral and bacterial infections.