In the present study, the Karun River in Khuzestan province in Iran is that is somehow considered the river with the most water in the country was examined. To examine the depth and speed of the flow, which undoubtedly have the greatest impact on the environment and ecosystem of the river, twodimensional simulation by CCHE2D model was used. In this study, it was observed that, firstly, the changes of depth and velocity along the river have good coordination and the highest changes were observed in the meander and arches. Moreover, due to using two-dimensional model, there is the possibility of examining changes of parameters in the longitudinal and transverse direction that shows the two-dimensional model is an efficient and powerful model in studying river flows.