Introduction: According to epidemiological studies, NAFLD affects 9% to 53% of India's general population, with a higher frequency among those who are overweight or obese, those who have diabetes, or those who have prediabetes. There is emerging evidence of NAFLD occurring in lean or normal weight individuals. Studies show that between 5 and 34% of lean people have NAFLD. The highest prevalence rates, which were above 30%, were seen in India. Furthermore, Asian men who are slender, healthy, and active have insulin resistance prevalence that is three to four times higher than that of men in the rest of the world. Aim: To access the prevalence and risk factors of NAFLD among lean individuals attending Gauhati Medical College & Hospital with diagnosed Fatty Liver Disease. Materials and methods: A Hospital based Cross sectional study was done. The Gastroenterology department was used to choose the study participants using a purposive sampling method. The sample was made up of all patients with fatty liver disease who visited the gastroenterology outpatient department. The study found that the prevalence of NAFLD in lean individuals is Result: 16.9%. Females are at higher risk (P=0.0313 OR: 0.08316) of developing NAFLD in lean patients. Diabetes (P=0.0260 OR: 3.667) and Hypertension (P=0.0149 OR: 4.189) are signicant risk factors. Altered bilirubin levels (P=0.0035 OR: 5.829), lipid prole (P=0.0013 OR: 7.367) and AST/ALT (P=0.0166 OR: 4.321) levels is also associated with NAFLD in lean individuals. NAFLD affects 16.9% of lean Conclusion: people with a BMI under 23. Among the lean population, women have a higher chance of getting NAFLD than men. In the study population, important risk factors for NAFLD include diabetes and hypertension. Patients with NAFLD (BMI <23) are more likely to have abnormal lipid proles, AST/ALT values and bilirubin levels than non-NAFLD fatty liver patients with BMI <23

No abstract

BACKGROUND Considering the heavy toll taken by COVID- 19 pandemic, the understanding of the epidemiological parameters as well as various risk factors is crucial for future preparedness and tackling the pandemic in a more effective manner. We wanted to study the socio-demographic correlates of COVID -19 cases in Assam, India. Also to find the relationship of clinical status of COVID -19 cases with co- morbidities and with substance use. METHODS An institution-based cross-sectional study was undertaken from 1st April 2020 to 31st August 2020. Out of the total 12 COVID Care Centres / hospitals that had been established in Kamrup and Kamrup Metro districts of Assam, 6 were randomly selected. A total of 3000 patients were interviewed over telephone by using an android-based application; on or after discharge from the centres, while patient was put on mandatory quarantine. The patients were interviewed on various sociodemographic variables, co-morbidities and substance use behaviour. Categorical variables are expressed as percentages and the continuous variables are expressed as mean ± standard deviation. t-test and chi-square test were used for continuous and categorical variables respectively. RESULTS Mean age of moderate and severe cases were 55.10 and 55.9 years respectively. Smoking and use of alcohol were significantly associated with severity of symptoms. Diabetes, hypertension and co-existing lung diseases were found to be associated with status of symptoms. CONCLUSIONS Epidemiological risk factors like age has to be relooked. Primary prevention on risk factors of non-communicable diseases proved to be crucial in prevention of severity of communicable pandemic like COVID-19. Further studies are required to enhance the knowledge on this aspect. KEY WORDS COVID-19, Substance Use, Diabetes, Hypertension, Lung Diseases, Status of Symptoms.