Over the past decades, numerous occupational therapy frameworks have been published and adopted in the West but there is little discussion of their applicability to Singapore. The purpose of this study was to examine the relevance and applicability of occupational therapy frameworks in Singapore. Data were gathered from nine highly experienced occupational therapists. Audio-taped semi-structured interviews were used to collect data. Qualitative methods were used in identifying five themes--independence, applicability of client-centred practice, concepts of occupation/activity, client's areas of concern, and application of occupational therapy models to practice. The themes were discussed in the context of three broad areas: (1) the potential discrepancy between occupational therapy's philosophical base and clients' values, (2) mismatch between the occupational therapists' prescription of activity and the meaning of activities to clients, and (3) the potential conflict between the occupational therapy approach and the corporate culture in Singapore. One of the important results from the study was that in Singapore culture, clients generally did not believe that achieving independence was important and they expected to be taken care of by their families. Further research with a larger sample is necessary to explore how culture and societal values impact on occupational therapy practice in Singapore.