Designing urban landscapes for climate change adaptation and mitigation is highly promoted for contemporary urban development. However, the lack of climate-based design knowledge and techniques in existing urban landscape practice has challenged the implementation. This paper, therefore, introduced climate-led as a practical approach for urban landscape design to overcome such a dilemma. This approach was results-oriented with integrated use of microclimate, thermal comfort, and GIS modelling and simulation tools. Through the computer-based scenarios building and comparison, this paper has analyzed and figured out efficient landscape designs for microclimate and thermal comfort improvement in Ipoh, Malaysia. In this case, shading most determined the level of cooling and pedestrian thermal comfort, leading the effective street tree planting became an essential measure in the tropical climate-led plan. Besides, this study found that wind did not positively influence thermal comfort due to site characteristic at a particular time, in contrast with other hot regions. In conclusion, developing climate-led landscape and greenery in urban design is a functional initiative for urban cooling and sustainable urban development. Furthermore, the application of modelling and simulation methods in urban landscape design can reduce the possibility of failure in practice, thereby promising urban efficiency in response to climate change.