Background: Condylomata Acuminata (CA) is a sexually transmitted disease caused by the Human Papilloma Virus (HPV) type-specific and may be simultaneously co-infected with other HPV types associated with malignancy. Purpose: To differentiate between CA and histopathological of malignancy by immunohistochemistry. LiteratureReview: CA refers to benign epidermal proliferation caused by the HPV types 6 and 11, but co-infection with highrisk HPV types are common. The clinical presentation of CA can't differentiate between benign or preneoplastik diplasia lesions. Koilocytes considered pathognomonic for HPV lesions, these findings sometimes don't appear on CA, and histopathology was not accurate, that immunohistochemistry with MIB-1 (Ki-67) and p16 can beused. Conclusion: Immunohistochemistry examination can help differentiate the diagnosis between malignancy or nonmalignancy in the case of CA. ABSTRAKLatar Belakang: Kondilomata Akuminata (KA) merupakan penyakit menular seksual yang disebabkan Human Papilloma Virus (HPV) tipe tertentu dan mungkin dapat terinfeksi secara bersamaan dengan tipe HPV lain yang terkait dengan keganasan. Tujuan: untuk membedakan gambaran histopatologi antara KA dan keganasan dengan pemeriksaan imunohistokimia. Telaah Kepustakaan: KA mengacu pada proliferasi epidermal jinak yang disebabkan HPV tipe 6 dan 11, tapi ko-infeksi dengan HPV tipe risiko tinggi sering terjadi. Gambaran klinis pada KA tidak dapat membedakan lesi jinak dari preneoplastik atau lesi diplastik. Koilositosis dianggap patognomonik lesi HPV, temuan ini kadang-kadang tidak tampak pada KA, dan histopatologi tidak tepat, sehingga dapat menggunakan pemeriksaan imunohistokimia dengan biomarker MIB-1(ki-67) dan p16. Kesimpulan: Pemeriksaaan imunohistokimia dapat membantu mendiagnosis banding pada kasus KA yang samar-samar maupun keganasan.

Introduction: Black cumin (Nigella sativa) is widely used to treat various diseases. It is also believed to relief skin conditions accompanied by itching symptom, such as atopic dermatitis (AD) or eczema. However, the anti-eczema mechanism of action is still unclear. The aims of this syudy was to  identify anti-eczema mechanism of action of N. sativa for AD using computer aided prediction and pathway analysis based on protein-chemical networks. Methods: We utilized dataset consisting chemical compounds of N. sativa from KNApSAcK. It is a comprehensive species-metabolite relationship database. Using canonical SMILES strings that encode molecular structures of each compound, we predicted the probabilities of activity (Pa) for anti-eczema effect based on PASS algorithms. The compounds with Pa >0.7 were included for pathway analysis based on protein-chemical interaction networks in STITCH database. We selected interactomes built by experimental data, gene co-expression, closest gene position, fusion, co-occurence, computational prediction, and other secondary data. Results: Thirty-five active compounds of N. sativa have been utilized and 19 of them have potential anti-eczema effects. Oleic acid and lauric acid were predicted with Pa-value of 0.947 and 0.920 for anti-eczema effect, respectively. However, only lauric acid was confirmed having a plausible mechanism of action via LY96-TLR4- PIK3R1 pathway for lipopolysaccharide receptor activity (false discovery rate [FDR] = 0.0243) and low-density lipoprotein particle receptor binding (FDR = 0.0118). Conclusion: Lauric acid in N. sativa has potential antieczema effect to prevent relaps in AD patients by controlling opportunistic bacterial infection that aggravates itching symptom in this condition.

Introduction: The inflammatory process underlies either osteoarthritis (OA) or metabolic syndrome. Systemic inflammation that occurs in the metabolic syndrome will result in the production of inflammatory cytokines and activation of macrophages and chondrocytes. This can affect the entire body including joints and the surrounding tissues, causing OA. Type 2 Diabetes Mellitus (DMT2) and hypertension are the first and second most common metabolic syndrome components found in OA patients. This study aimed to determine the relationship between metabolic syndrome and knee OA in DMT2 patients with hypertension. Methods: By using an analytic observational method and cross-sectional design, this study involved the medical records of patients with DMT2. The sample consisted of 50 medical records selected by using the purposive sampling technique and fulfilling the inclusion and exclusion criteria. Results: This study involved 25 medical records of patients with and without knee (genu) OA. The characteristics of the sample were as follows: 1 medical record of patient aged 36-45 years, 18 medical records of patients aged 46-55 years, 16 medical records of patients aged 56-65 years, 15 medical records of patients aged > 65 years, 21 medical records of male patients, 29 medical records of female patients, 27 medical records with metabolic syndrome, and 23 medical records without metabolic syndrome. The association between metabolic syndrome and knee (genu) OA was analyzed by using the Chi-Square Test using the SPSS application, where the results showed a significance value of p < 0.05 (p = 0.001). Conclusion: This study shows that there is a significant association between metabolic syndrome and knee (genu) OA.

Community service programs based on science and technology as a medium for mentoring prospective entrepreneurs in Rangkah district. Tambak Sari Kenjeran Surabaya, East Java. As partners are craftsmen of Various srundeng and sambal and young people who have connections as entrepreneurs from various groups in the target areas of the activity. The problem faced is that all this time the roasting process of srundeng and sambal sprinkles uses the conventional method, namely by using a frying pan that contains oil so it is unhealthy because it causes cholesterol and easily changes aroma. In carrying out the business activities of making srundeng and sambal sprinkled with sea fish, partners have not applied science and technology as well as potential entrepreneur partners. Many young people from various backgrounds in Rangkah Kenjeran Surabaya which has links as entrepreneurs but no one has yet facilitated assistance. As a solution for this community service program is to use a roaster with a capacity of 15kg / hour with dimensions specifications: 133x63x110cm, fuel: LPQ, 450watt electricity, 220v, to increase production capacity. Second, given training in mentoring concept knowledge and understanding of socio-spiritual and technological insight into marketing activities. Furthermore, providing training on creativity and innovation in the manufacture of products from marine fish from the Kenjeran coastal area to activity partners. The methods of implementation are (1) design, build, maintenance and use of roaster machines (2) training, practice, and assistance to increase conceptual competence and understanding of social and spiritual marketing for partners. (3) Training, practice, and mentoring transmit the mindset and behavior of an entrepreneur to students so that they behave and be entrepreneurial for partners. The results of this activity show a positive impact in improving the quality of partner products and increasing understanding, especially in entrepreneurship in improving their business going forward.