Scabies is a contagious skin infection caused by infestation and sensitization of female mites Sarcoptes scabiei varieta hominis and its products. Scabies is also known as The Itch, Sky-Bees, Scabies, and Itchy Agogo. The prevalence of scabies in developing countries, including Indonesia is 4.6% -12.95% and the third of the 12 most common skin diseases that occur in the community. The most dominant factor is knowledge and behavior factors. The purpose of this study was to analyze the relationship between the level of knowledge and the clean behavior and healthy lifestyle on the incidence of scabies in students. The research method was observational analytic with cross sectional observation. A sample of 34 people was taken by simple random technique. Data is taken through physical examination and using a questionnaire. Data were analyzed using the Chi Square Test statistic test. The results showed that there was a significant relationship between the level of knowledge with the incidence of scabies (p=0,007) and there was a significant relationship between the level of clean and healthy living behavior with the incidence of scabies (p=0,015). The results of research, a very important factor related to scabies is lack of knowledge and poor personal hygiene problems.