The synthesis of N-heterocycles composes a significant part of synthetic chemistry. In this report, a Cu(II)-catalyzed green and efficient synthesis of pyrrolo[1,2-a]quinoxaline, quinazolin-4-one, and benzo[4,5]imidazoquinazoline derivatives was developed, employing N,N-dimethylethanolamine (DMEA) as a C1 synthon. Green oxidant O 2 is critical in these transformations, facilitating the formation of a key intermediate�a reactive iminium ion. The method conducted under mild conditions is compatible with a diversity of functional groups, providing an appealing alternative to the previously developed protocols.

Herein, a Cu(II)-catalyzed facile construction of synthetically valuable spiro compounds from β-Naphthols under air is reported, in which N,N-dimethylaminoethanol (DMEA) serves as an efficient and unique C1 synthon. This transformation...

A green and facile synthesis of previously unreported C,N-disulfonated 5-amino pyrazoles was established through iodine-catalyzed cascade reaction of easily accessible sulfonyl hydrazides, β-ketonitriles, and sodium sulfinates. Diverse C,N-disulfonated 5-amino pyrazoles...