This study was conducted with an objective of assessing the level of job satisfaction and its determinants among agricultural development agents working in different kebeles of Kalu Woreda, South Wollo Zone of the Amhara National Regional State. A total of 100 development agents were selected and interviewed using simple random sampling technique to collect data for the study through structured questionnaire. Descriptive and multiple regression methods were used to address the study objectives. Results of descriptive analysis showed that in terms of the level of job satisfaction of development agents on average development agents are 'undecided' with their job as a result of their involvement in special projects such as agriculture growth projects and donor-funded projects, in decision making, in in-service training and working relationship with farmers. The econometric results showed that there exists a statistically significant relationship between job satisfaction and recognition for best performances, rate of promotion, regular training and level of education of development agents. The study recommends that due attention needs to be given to defining career structure and provision of service training opportunities as criteria in promoting, improving and maintaining their job satisfaction.