Objective Disability not only affects the disabled child. It also has psychological and social impacts on family members and caregivers. The purpose of the study was to determine the relationship between severity of depressive symptomes and hopelessness levels of caregivers of children with disabilities and their perceived social support. Materials and MethodsA total of 205 caregivers of disabled children were included in this cross-sectional study. A 'sociodemographic questionnaire' , 'Beck Depression Scale' , 'Beck Hopelessness Scale' and 'Multidimensional Perceived Social Support Scale' were used to assess the subjects in this cross-sectional study. Direct and indirect effects of a predictor in path models of mediation and moderation were calculated. The bootstrapping method has been used to calculate confidence intervals for indirect effects.Results It was determined that the hopelessness levels were high (r = 0.594, p <.001) for individuals with high levels of depressive symptomes, the perceived social support was low for caregivers with high hopelessness levels (r = −0.149, p =.033), and that the perceived social support levels were low for caregivers with high levels of depressive symptomes (r=−0.128, p =.068). It was shown that hopelessness increases, and depression develops indirectly with decreasing psychosocial support. ConclusionThis study reveals the importance of perceived social support in the development of hopelessness and depression, which increase the burden of caregivers. Increasing the psychosocial support systems of caregivers of children with disabilities can reduce their levels of hopelessness and depression and increase their ability to care.